1-Fluoro-2,4-dinitrobenzene
1-Fluoro-2,4-dinitrobenzene (CAS: 70-34-8) is a pale yellow crystalline solid with the molecular formula (O2N)2C6H3F and a molecular weight of 186.10 g/mol. This compound functions as a key fluorinated building block in organic synthesis, particularly in the preparation of various functionalized aromatic compounds. Its reactivity makes it valuable in derivatization reactions and as a reagent in analytical chemistry. Tech Serve Solutions supplies this chemical for research and development purposes.
- IUPAC
- 2,4-Dinitro-1-fluorobenzene,DNFB,DNPF,FDNB,Sanger reagent
- Synonyms
- 2,4-Dinitro-1-fluorobenzeneDNFBDNPFFDNBSanger reagent
Organic Synthesis Intermediate
1-Fluoro-2,4-dinitrobenzene serves as a versatile intermediate in the synthesis of diverse organic molecules. It is frequently employed in nucleophilic aromatic substitution reactions to introduce the 2,4-dinitrophenyl group into various substrates.
Biochemical Reagent
Historically known as Sanger's reagent, this compound is used for the identification and quantification of N-terminal amino acids in peptides and proteins. It reacts with the free amino group to form a stable, chromophoric derivative.
Analytical Derivatization Agent
Its ability to react with primary and secondary amines makes it useful for derivatizing analytes in chromatographic analysis, improving their detection by UV or fluorescence spectroscopy.
| Molecular weight | 186.10 |
|---|---|
| Linear formula | (O2N)2C6H3F |
| Assay | ≥98.0% (GC) |
| Grade | purum p.a. |
| Boiling point | 178 °C/25 mmHg(lit.) |
| Density | 1.482 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.569(lit.) |
| Melting point | 25-27 °C(lit.) |
| Storage temperature | 2-8°C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H373CU
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, GlovesK: ≤100 mg/kg |
|---|---|
| Flash point | 164 °C / 327.2 °F |
| Water hazard class (WGK, DE) | 3Zn: ≤50 mg/kg |
| Hazard codes (EU) | XnNa: ≤100 mg/kg |
| Risk statements (R) | 22-33-36/37/38-43Ni: ≤50 mg/kg |
| Safety statements (S) | 26-36/37Pb: ≤50 mg/kg |
| Cation traces | Ca: ≤50 mg/kgCd: ≤50 mg/kgCo: ≤50 mg/kgCu: ≤50 mg/kgFe: ≤50 mg/kgK: ≤100 mg/kgNa: ≤100 mg/kgNi: ≤50 mg/kgPb: ≤50 mg/kgZn: ≤50 mg/kg |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Fluoro-2,4-dinitrobenzene used for?
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1-Fluoro-2,4-dinitrobenzene is primarily used as an intermediate in organic synthesis, a reagent for derivatizing amino acids and peptides (Sanger's reagent), and for analytical purposes.
What is the CAS number and chemical formula for 1-Fluoro-2,4-dinitrobenzene?
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The CAS number is 70-34-8, and its linear formula is (O2N)2C6H3F.
What grade and purity does Tech Serve Solutions supply for 1-Fluoro-2,4-dinitrobenzene?
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Tech Serve Solutions supplies 1-Fluoro-2,4-dinitrobenzene with a purity of ≥98.0% (GC), designated as 'purum p.a.' grade. This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 1-Fluoro-2,4-dinitrobenzene be handled safely?
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Handle 1-Fluoro-2,4-dinitrobenzene with appropriate personal protective equipment, including dust masks (type N95), eyeshields, faceshields, and gloves. It is classified as harmful if swallowed, causes skin irritation, may cause an allergic skin reaction, causes serious eye irritation, and may cause respiratory irritation. It may also cause damage to organs through prolonged or repeated exposure. Ensure adequate ventilation and avoid dust formation.
How is 1-Fluoro-2,4-dinitrobenzene packed and shipped?
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1-Fluoro-2,4-dinitrobenzene is stored at 2-8°C. TSS exports chemicals globally, adhering to all relevant shipping regulations for hazardous materials.
How can I request a sample or quote for 1-Fluoro-2,4-dinitrobenzene?
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To request a sample or a quote, please contact our sales team through the website or by phone, providing your specific requirements and shipping details.
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