1-Bromo-2-naphthoic acid
1-Bromo-2-naphthoic acid (CAS: 20717-79-7), with the molecular formula C11H7BrO2 and a molecular weight of 251.08, is a valuable organic building block. This carboxylic acid derivative of naphthalene serves as a key reactant in the synthesis of diverse complex molecules, including binaphthyl-based compounds, benzimidazoles, and axially chiral biaryls. Its utility extends to the creation of probes for enzymatic studies.
- IUPAC
- 1-Bromo-2-naphthalenecarboxylic acid
- Synonyms
- 1-Bromo-2-naphthalenecarboxylic acid
Synthesis of Binaphthyl Derivatives
This compound is a reactant in domino coupling reactions and lactam ring opening for the synthesis of binaphthyl-based amino acids and amino alcohols.
Benzimidazole Synthesis
1-Bromo-2-naphthoic acid is employed in cyclocondensation reactions to prepare benzimidazoles and their quinone derivatives.
Chiral Biaryl Preparation
It serves as a building block in Suzuki-Miyaura reactions for the synthesis of valuable axially chiral biaryl compounds.
Enzyme Probe Development
The compound is utilised in the synthesis of probes designed to investigate the activity of human cytochrome P450 enzymes.
| Molecular weight | 251.08 |
|---|---|
| Empirical formula | C11H7BrO2 |
| Application | Reactant involved in synthesis of:• Binaphthyl-based amino acids and amino alcohols via domino coupling reactions and lactam ring opening of intermediates1• Benzimidazoles and benzimidazolequinone derivatives via cyclocondensation2• Axially chiral biaryls via Suzuki-Miyaura reactions3• Aryl ring-fused benzimidazolequinones via radical cyclization4• Probes for human cytochrome P450 enzymes5• Phananthridinone derivatives via domino coupling reactions6 |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Bromo-2-naphthoic acid used for?
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1-Bromo-2-naphthoic acid is used as a reactant in the synthesis of various organic compounds, including binaphthyl-based amino acids and amino alcohols, benzimidazoles, axially chiral biaryls, and probes for human cytochrome P450 enzymes.
What are the CAS number and molecular formula for 1-Bromo-2-naphthoic acid?
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The CAS number is 20717-79-7 and the molecular formula is C11H7BrO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Bromo-2-naphthoic acid for research and chemical synthesis purposes. The specific assay/grade is not detailed in the provided data and is not represented as USP, BP, or EP grade.
What are the safety and handling considerations for 1-Bromo-2-naphthoic acid?
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1-Bromo-2-naphthoic acid is classified under WGK Germany 3, indicating it is hazardous to water. Appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter, should be used when handling this chemical.
How is 1-Bromo-2-naphthoic acid packed, shipped, and exported?
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1-Bromo-2-naphthoic acid is packed and shipped according to standard chemical handling protocols. As a global supplier, Tech Serve Solutions is experienced in exporting fine chemicals worldwide.
How can I request a quote or sample for 1-Bromo-2-naphthoic acid?
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To request a quote or a sample of 1-Bromo-2-naphthoic acid, please contact the Tech Serve Solutions sales team through the website or by phone.
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