1-Bromo-2,4-difluorobenzene
1-Bromo-2,4-difluorobenzene (CAS 348-57-2), with the molecular formula BrC₆H₃F₂, is a valuable fluorinated aryl building block. This compound, weighing 192.99 g/mol, is characterised by its high purity (98% assay). It serves as a key intermediate in organic synthesis, particularly in the preparation of complex pharmaceutical agents and other fine chemicals, owing to the reactivity imparted by the bromine and fluorine substituents.
- Synonyms
- BrC6H3F2
Pharmaceutical Intermediate Synthesis
This compound is utilised in the multi-step synthesis of pharmaceutical agents, including the preparation of key chiral intermediates for antifungal medications.
Organic Synthesis Building Block
1-Bromo-2,4-difluorobenzene serves as a versatile building block in organic chemistry for introducing the 2,4-difluorophenyl moiety into various molecular structures.
Precursor for Complex Molecules
It has been employed in the synthesis of advanced organic compounds, such as (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-sila-ethoxy)-propan-1-one.
| Molecular weight | 192.99 |
|---|---|
| Linear formula | BrC6H3F2 |
| Assay | 98% |
| Boiling point | 145-146 °C(lit.) |
| Density | 1.708 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.505(lit.) |
| Application | 1-Bromo-2,4-difluorobenzene has been used in:• preparation of (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-sila-ethoxy)-propan-1-one1• enantiomeric preparation of the key intermediate of chiral azole antifungal agents by a chemoenzymatic process2 |
| Melting point | −4 °C(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 52 °C / 125.6 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 16-26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Bromo-2,4-difluorobenzene used for?
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1-Bromo-2,4-difluorobenzene is primarily used as a building block in organic synthesis, particularly for preparing pharmaceutical intermediates and other complex organic molecules.
What is the CAS number and chemical formula for 1-Bromo-2,4-difluorobenzene?
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The CAS number is 348-57-2 and the linear formula is BrC₆H₃F₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Bromo-2,4-difluorobenzene with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 1-Bromo-2,4-difluorobenzene be handled safely?
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1-Bromo-2,4-difluorobenzene is a flammable liquid and vapour (H226) and can cause skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment including gloves, eyeshields, and respiratory protection should be used in a well-ventilated area.
How is 1-Bromo-2,4-difluorobenzene packed, shipped, and exported?
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1-Bromo-2,4-difluorobenzene is typically packed in compliance with international shipping regulations for hazardous materials. TSS exports globally, adhering to all necessary customs and transport protocols.
How can I request a sample or quote for 1-Bromo-2,4-difluorobenzene?
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To request a sample or a quote, please contact our sales department through the website or by phone, providing your required quantity and shipping details.
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