1-Boc-piperidine-4-carboxaldehyde
1-Boc-piperidine-4-carboxaldehyde (CAS: 137076-22-3, C11H19NO3) is a key heterocyclic building block with a molecular weight of 213.27 g/mol. This piperidine derivative, featuring a Boc-protected nitrogen and an aldehyde functional group, serves as a versatile intermediate in organic synthesis. Its primary utility lies in the preparation of complex molecules, including pharmaceutical agents targeting various diseases, and in facilitating multi-component reactions.
- IUPAC
- 4-Formylcyclohexanecarboxylic acid tert-butyl ester,tert-Butyl 4-formylpiperidine-1-carboxylate
Pharmaceutical Intermediate
1-Boc-piperidine-4-carboxaldehyde is utilised as a reactant in the synthesis of various biologically active compounds. These include Pim-1 inhibitors, selective GPR119 agonists for type II diabetes, and M-tropic (R5) HIV-1 replication inhibitors.
Synthesis of HDAC Inhibitors and 5-HT6 Antagonists
This compound serves as a precursor in the development of histone deacetylase (HDAC) inhibitors and selective 5-HT6 receptor antagonists, both important classes of therapeutic agents.
Three-Component Vinylogous Mannich Reactions
The aldehyde functionality makes 1-Boc-piperidine-4-carboxaldehyde suitable as a reactant in three-component vinylogous Mannich reactions, enabling efficient construction of complex molecular architectures.
| Molecular weight | 213.27 |
|---|---|
| Empirical formula | C11H19NO3 |
| Assay | 95% |
| Storage temperature | 2-8°C |
| Application | Reactant for synthesis of:• Pim-1 inhibitors1• Selective GPR119 agonists for type II diabetes2• M-tropic (R5) HIV-1 replication inhibitors3• HDAC inhibitors4• Selective 5-HT6 antagonists5Reactant for three-component vinylogous Mannich reactions6 |
| Melting point | 34-40 °C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H400Very toxic to aquatic life
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P305IF IN EYES
| Flash point | >110 °C / >230 °F |
|---|---|
| Transport (UN / ADR) | UN 3077 9 / PGIII |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 22-36/37/38-50 |
| Safety statements (S) | 26-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Boc-piperidine-4-carboxaldehyde used for?
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1-Boc-piperidine-4-carboxaldehyde is used as a versatile intermediate in organic synthesis, particularly for the preparation of pharmaceutical agents such as Pim-1 inhibitors, selective GPR119 agonists, HIV-1 replication inhibitors, HDAC inhibitors, and selective 5-HT6 antagonists. It is also a reactant in three-component vinylogous Mannich reactions.
What are the CAS number and formula for 1-Boc-piperidine-4-carboxaldehyde?
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The CAS number for 1-Boc-piperidine-4-carboxaldehyde is 137076-22-3, and its empirical formula is C11H19NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Boc-piperidine-4-carboxaldehyde with a minimum assay of 95%. TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should 1-Boc-piperidine-4-carboxaldehyde be handled and stored?
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1-Boc-piperidine-4-carboxaldehyde is classified as harmful if swallowed, causes skin irritation, causes serious eye irritation, may cause respiratory irritation, and is very toxic to aquatic life. It should be handled with appropriate personal protective equipment in a well-ventilated area. Store at 2-8°C.
Is 1-Boc-piperidine-4-carboxaldehyde available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 1-Boc-piperidine-4-carboxaldehyde.
How can I request a sample or quote for 1-Boc-piperidine-4-carboxaldehyde?
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Please contact our sales team via the website or by telephone to request a sample or a quotation for 1-Boc-piperidine-4-carboxaldehyde.
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