1-Bis(4-fluorophenyl)methyl piperazine
1-Bis(4-fluorophenyl)methyl piperazine (CAS: 27469-60-9), with the molecular formula C17H18F2N2 and a molecular weight of 288.34 g/mol, is a fluorinated heterocyclic compound. As a valuable building block in organic synthesis, it features a piperazine core substituted with a difluorobenzhydryl group. This chemical is primarily utilised in research and development, particularly in the synthesis of more complex molecules within the pharmaceutical and chemical industries.
- IUPAC
- 1-(4,4′-Difluorobenzhydryl)piperazine

Organic Synthesis Intermediate
This compound serves as a versatile intermediate in the construction of novel organic molecules. Its unique difluorobenzhydryl and piperazine moieties offer specific reactivity for further chemical transformations.
Pharmaceutical Research
It is employed in medicinal chemistry programmes for the development of new therapeutic agents. The presence of fluorine atoms can often enhance the pharmacokinetic properties of drug candidates.
Chemical Building Block
As a fluorinated heterocyclic building block, it is useful for introducing specific structural features into target compounds, facilitating the exploration of chemical space.
| Molecular weight | 288.34 |
|---|---|
| Empirical formula | C17H18F2N2 |
| Assay | 97% |
| Melting point | 88-92 °C(lit.) |

Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-36/37/38 |
| Safety statements (S) | 26-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Bis(4-fluorophenyl)methyl piperazine used for?
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1-Bis(4-fluorophenyl)methyl piperazine is primarily used as a building block and intermediate in organic synthesis and pharmaceutical research for the development of new chemical entities.
What are the CAS number and molecular formula?
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The CAS number for 1-Bis(4-fluorophenyl)methyl piperazine is 27469-60-9, and its molecular formula is C17H18F2N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Bis(4-fluorophenyl)methyl piperazine with an assay of 97%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should this chemical be handled and stored?
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Handling requires appropriate personal protective equipment, including eyeshields, face shields, gloves, and a P2 respirator. The compound is labelled with Danger signal word and hazards including H301 (Toxic if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Store in accordance with safety data sheet recommendations.
Is 1-Bis(4-fluorophenyl)methyl piperazine a controlled substance?
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The provided data does not indicate that 1-Bis(4-fluorophenyl)methyl piperazine is a scheduled or controlled substance.
How is this product packed and shipped?
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Tech Serve Solutions exports chemicals globally, adhering to international shipping regulations. Specific packaging details are available upon request.
How can I request a quote or sample?
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To request a quote or a sample of 1-Bis(4-fluorophenyl)methyl piperazine, please contact our sales department through the website or by phone.
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