1,4-Dibromo-2,5-difluorobenzene
1,4-Dibromo-2,5-difluorobenzene (CAS 327-51-5) is a halogenated aromatic compound with the molecular formula Br2C6H2F2 and a molecular weight of 271.88 g/mol. This compound serves as a valuable building block in organic synthesis. Its primary applications involve its use in the preparation of more complex fluorinated organic molecules, including phosphine ligands and polymer precursors, for advanced materials research and development.
- Synonyms
- 327-51-5Br2C6H2F2

Synthesis of Phosphine Ligands
1,4-Dibromo-2,5-difluorobenzene is a key precursor for synthesising specialised 1,2,4,5-tetrakis(phosphino)-3,6-difluorobenzene ligands. These ligands are crucial in catalysis and coordination chemistry research.
Preparation of Fluorinated Polymers
This dibromobenzene derivative has been employed in the synthesis of novel fluorinated polymers, such as poly(2,5-difluoro-2′,5′-didodecyl-4,4′-biphenylene). Such polymers can exhibit unique electronic and material properties.
Organic Synthesis Building Block
As a difluorinated and dibrominated benzene derivative, it offers reactive sites for various cross-coupling and substitution reactions, enabling the construction of complex organic architectures.
| Molecular weight | 271.88 |
|---|---|
| Linear formula | Br2C6H2F2 |
| Assay | 98% |
| Boiling point | 96 °C/20 mmHg(lit.) |
| Application | 1,4-Dibromo-2,5-difluorobenzene has been used in the preparation of:• 1,2,4,5-tetrakis(phosphino)-3,6-difluorobenzenes1• poly(2,5-difluoro-2′,5′-didodecyl-4,4′-biphenylylene2 |
| Melting point | 60-62 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,4-Dibromo-2,5-difluorobenzene primarily used for?
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1,4-Dibromo-2,5-difluorobenzene is primarily used as a building block in organic synthesis, particularly for preparing fluorinated phosphine ligands and polymers.
What is the CAS number and formula for 1,4-Dibromo-2,5-difluorobenzene?
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The CAS number is 327-51-5 and the linear formula is Br2C6H2F2.
What grade and purity does Tech Serve Solutions supply for 1,4-Dibromo-2,5-difluorobenzene?
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Tech Serve Solutions supplies 1,4-Dibromo-2,5-difluorobenzene with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 1,4-Dibromo-2,5-difluorobenzene be handled?
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1,4-Dibromo-2,5-difluorobenzene is a Warning substance that may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
Can Tech Serve Solutions export 1,4-Dibromo-2,5-difluorobenzene?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and can fulfil export orders for 1,4-Dibromo-2,5-difluorobenzene.
How can I request a quote or sample for 1,4-Dibromo-2,5-difluorobenzene?
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Please contact our sales team via the website or direct email to request a quotation or a sample of 1,4-Dibromo-2,5-difluorobenzene.
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