1,4-Di-Boc-piperazine-2-carboxylic acid
1,4-Di-Boc-piperazine-2-carboxylic acid (CAS: 181955-79-3) is a protected piperazine derivative with the molecular formula C15H26N2O6 and a molecular weight of 330.38 g/mol. This heterocyclic building block is primarily utilised in chemical synthesis, particularly for the preparation of more complex molecules and pharmaceutical intermediates. It is supplied with an assay of 97% and requires storage at 2-8°C.
- IUPAC
- 1,4-Bis(Boc)piperazine-2-carboxylic acid,1,4-Bis(tert-butoxycarbonyl)piperazine-2-carboxylic acid,Piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester
- Synonyms
- 1,4-Bis(Boc)piperazine-2-carboxylic acid1,4-Bis(tert-butoxycarbonyl)piperazine-2-carboxylic acidPiperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester

Pharmaceutical Intermediate Synthesis
This compound serves as a valuable intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its protected piperazine core allows for regioselective functionalization in multi-step synthetic routes.
Organic Synthesis Building Block
As a functionalised piperazine, it is employed in general organic synthesis to introduce the piperazine moiety into target molecules. The Boc protecting groups facilitate controlled reactions and subsequent deprotection steps.
Research and Development
Researchers utilise 1,4-Di-Boc-piperazine-2-carboxylic acid in academic and industrial R&D settings to explore novel chemical entities and synthetic methodologies.
| Molecular weight | 330.38 |
|---|---|
| Empirical formula | C15H26N2O6 |
| Assay | 97% |
| Storage temperature | 2-8°C |
| Melting point | 142-148 °C |

Hazard statements
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36-43 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,4-Di-Boc-piperazine-2-carboxylic acid used for?
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1,4-Di-Boc-piperazine-2-carboxylic acid is used as a building block in organic synthesis, particularly for the preparation of pharmaceutical intermediates and other complex organic molecules.
What is the CAS number and formula for 1,4-Di-Boc-piperazine-2-carboxylic acid?
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The CAS number is 181955-79-3 and the empirical formula is C15H26N2O6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,4-Di-Boc-piperazine-2-carboxylic acid with an assay of 97%. TSS does not represent this product as USP, BP, or EP grade.
How should 1,4-Di-Boc-piperazine-2-carboxylic acid be handled?
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Warning: May cause an allergic skin reaction (H317) and serious eye irritation (H319). Wear protective gloves and eye protection (P280, P305 + P351 + P338). Avoid breathing dust/fume/gas/mist/vapours/spray.
How is this chemical shipped and exported?
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Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals, ensuring compliant packaging and documentation for international shipments.
How can I request a sample or quote for 1,4-Di-Boc-piperazine-2-carboxylic acid?
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Please contact our sales team via the website or direct enquiry for sample requests or a formal quotation.
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