1,4-Bis(trimethylsilyl)butadiyne

CAS 4526-07-2(CH3)3SiC≡CC≡CSi(CH3)3Chemical Synthesis

1,4-Bis(trimethylsilyl)butadiyne (CAS: 4526-07-2) is a notable organic compound with the molecular formula (CH3)3SiC≡CC≡CSi(CH3)3 and a molecular weight of 194.42 g/mol. This compound serves as a valuable building block in organic synthesis. Its unique structure featuring a diyne core flanked by trimethylsilyl groups makes it useful for specific chemical transformations, including its application in Negishi protocols for the synthesis of complex molecules.

IUPAC: 1,4-Bis(trimethylsilyl)-1,3-butadiyne,BTMSBD
Synonyms: (CH3)3SiC≡CC≡CSi(CH3)31,4-Bis(trimethylsilyl)-1,3-butadiyneBTMSBD

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1,4-Bis(trimethylsilyl)butadiyne ((CH3)3SiC≡CC≡CSi(CH3)3) — chemical structure, CAS 4526-07-2; Chemistry, fine chemical supplied by Tech Serve Solutions

AlkynesBuilding BlocksChemical SynthesisInternalOrganic Building Blocks

01 /Applications

Synthesis of Oligo(ethynylene)s

1,4-Bis(trimethylsilyl)butadiyne is employed in Negishi coupling reactions for the construction of glycosylated oligo(ethynylene) chains, contributing to the development of novel carbohydrate-based materials and compounds.

Organic Building Block

This compound functions as a versatile organic building block in synthetic chemistry. The trimethylsilyl groups can be selectively removed or retained, offering synthetic flexibility for creating diverse molecular architectures.

Chemical Synthesis

Utilized in various chemical synthesis pathways, it enables the introduction of the butadiyne unit into larger molecular frameworks. This is particularly useful for creating conjugated systems or rigid molecular scaffolds.

02 /Properties

Molecular weight	194.42
Linear formula	(CH3)3SiC≡CC≡CSi(CH3)3
Assay	98%
Density	0.974 g/mL at 20 °C(lit.)
Refractive index	n20/D 1.384(lit.)
Storage temperature	2-8°C
Application	1,4-Bis(trimethylsilyl)butadiyne has been used in Negishi protocol for the synthesis of glycosylated oligo(ethynylene)s1.
Melting point	111-113 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

Danger

Hazard statements

H228Flammable solid

Precautionary statements

P210Keep away from heat, sparks and open flames. No smoking

Protective equipment	Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 1325 4.1 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	F
Risk statements (R)	11
Safety statements (S)	16-22-24/25

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

4526-07-2

MDL number

MFCD00009839

PubChem substance

24855983

Beilstein registry

1758268

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 1,4-Bis(trimethylsilyl)butadiyne used for?

1,4-Bis(trimethylsilyl)butadiyne is used as a building block in organic synthesis, particularly in Negishi coupling reactions for creating glycosylated oligo(ethynylene)s and other complex conjugated molecules.

What is the CAS number and formula for 1,4-Bis(trimethylsilyl)butadiyne?

The CAS number is 4526-07-2, and the linear formula is (CH3)3SiC≡CC≡CSi(CH3)3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 1,4-Bis(trimethylsilyl)butadiyne with an assay of 98%. We do not represent this product as USP, BP, or EP grade.

How should 1,4-Bis(trimethylsilyl)butadiyne be handled?

1,4-Bis(trimethylsilyl)butadiyne is flammable (H228) and requires careful handling. Use appropriate personal protective equipment, including eyeshields, gloves, and a respirator (type N100 US or P3 EN143). Store at 2-8°C and keep away from ignition sources (P210).

Is 1,4-Bis(trimethylsilyl)butadiyne a controlled substance?

The provided data does not indicate that 1,4-Bis(trimethylsilyl)butadiyne is a controlled substance.

How is this chemical shipped and exported?

1,4-Bis(trimethylsilyl)butadiyne is classified for transport as UN 1325, Hazard Class 4.1, Packing Group II. TSS exports chemicals globally, adhering to all relevant shipping regulations.