1,4-Benzodioxan-6-amine
1,4-Benzodioxan-6-amine (CAS: 22013-33-8) is an organic chemical compound with the molecular formula C8H9NO2 and a molecular weight of 151.16 g/mol. This amine-based benzodioxane derivative serves as a valuable building block in chemical synthesis. It is primarily utilised in the development of complex organic molecules, including those with potential pharmaceutical applications.
- IUPAC
- 6-Amino-1,4-benzodioxan
- Synonyms
- 6-Amino-1,4-benzodioxan1,4-Benzodioxan-6-amine
Synthesis of Anti-Tumour Agents
1,4-Benzodioxan-6-amine has been employed in the synthesis of N-(2-hydroxy-ethyl)-2,3-didehydroazapodophyllotoxins, which have demonstrated anti-tumour activity. This highlights its utility in the creation of complex, biologically active molecules.
Precursor for Dioxanoacridinones
The compound serves as a key intermediate in the preparation of dioxanoacridinones. These heterocyclic structures are of interest in medicinal chemistry and materials science.
Organic Building Block
As a versatile heterocyclic building block, 1,4-Benzodioxan-6-amine is utilised in various organic synthesis pathways for the construction of novel chemical entities.
| Molecular weight | 151.16 |
|---|---|
| Empirical formula | C8H9NO2 |
| Assay | ≥98% |
| Density | 1.231 g/mL(lit.) |
| Refractive index | n20/D 1.599(lit.) |
| Application | 1,4-Benzodioxan-6-amine was used in the synthesis of N-(2-hydroxy-ethyl)-2,3-didehydroazapodophyllotoxins having anti-tumor activity1 and dioxanoacridinones2. |
| Melting point | 29-31 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,4-Benzodioxan-6-amine used for?
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1,4-Benzodioxan-6-amine is used in chemical synthesis, particularly for the preparation of compounds with potential anti-tumour activity and dioxanoacridinones. It functions as a valuable organic building block.
What is the CAS number and formula for 1,4-Benzodioxan-6-amine?
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The CAS number for 1,4-Benzodioxan-6-amine is 22013-33-8, and its empirical formula is C8H9NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,4-Benzodioxan-6-amine with a purity of ≥98%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
How should 1,4-Benzodioxan-6-amine be handled safely?
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1,4-Benzodioxan-6-amine is classified with hazards including H302 (Harmful if swallowed), H312 (Harmful in contact with skin), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H332 (Harmful if inhaled), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, such as eyeshields, gloves, and respiratory protection, should be used. Handle in a well-ventilated area.
How is 1,4-Benzodioxan-6-amine packed and shipped?
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1,4-Benzodioxan-6-amine is carefully packed to ensure safe transport and is exported globally by Tech Serve Solutions. Specific packaging details are available upon request.
How can I request a quote or sample?
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To request a quote or a sample of 1,4-Benzodioxan-6-amine, please contact our sales department via the website or direct telephone line.
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