1-(3-Pyridinylsulfonyl)-1H-benzotriazole
1-(3-Pyridinylsulfonyl)-1H-benzotriazole (CAS 678173-43-8; C11H8N4O2S; molar mass 260.27 g/mol) is a benzotriazole-based synthetic reagent supplied as a crystalline solid melting at 136-140 °C. In this N-sulfonylbenzotriazole, the benzotriazolyl group acts as a stable, controllable leaving group, making the compound a convenient pyridine-3-sulfonyl transfer reagent for chemical synthesis. Tech Serve Solutions supplies it at 95% assay for research and process development. It is offered as a research/reagent grade.
- Synonyms
- 1-(3-Pyridinylsulfonyl)-1H-benzotriazole1-(pyridine-3-sulfonyl)-1H-benzotriazole1-(pyridin-3-ylsulfonyl)-1H-benzo[d][1,2,3]triazole3-(1H-benzotriazol-1-ylsulfonyl)pyridine3-(benzotriazol-1-ylsulfonyl)pyridinebenzotriazol-1-yl 3-pyridyl sulfone
Pyridine-3-sulfonyl transfer reagent
The benzotriazolyl group is a good leaving group, so this reagent delivers a pyridine-3-sulfonyl unit to nucleophiles such as amines and alcohols under mild conditions. It offers a stable, easily handled alternative to the corresponding sulfonyl chloride.
C-S and C-X (non-halogen) bond formation
Used in chemical synthesis to construct carbon-sulfur and other carbon-heteroatom bonds without relying on halogenated intermediates. This supports cleaner reaction profiles in methodology and route-scouting work.
Sulfonamide and sulfonate ester synthesis
Reaction with amines or alcohols gives the corresponding sulfonamides and sulfonate esters bearing a 3-pyridyl group. Such motifs are common building blocks in medicinal chemistry and ligand design.
Benzotriazole-mediated synthetic methodology
Belongs to the established family of benzotriazole reagents valued for crystallinity, bench stability and predictable reactivity. It is suited to exploratory synthesis and the preparation of functionalised intermediates.
Research and process development
Supplied at 95% assay for use as a laboratory reagent in academic and industrial R&D. Appropriate analytical verification is recommended before use in any defined application.
| Molecular weight | 260.27 |
|---|---|
| Empirical formula | C11H8N4O2S |
| Assay | 95% |
| Application | New Benzotriazole Reagents |
| Melting point | 136-140 °C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(3-Pyridinylsulfonyl)-1H-benzotriazole used for?
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It is used as a benzotriazole-based sulfonyl transfer reagent in chemical synthesis. The benzotriazolyl group leaves readily, allowing the compound to deliver a pyridine-3-sulfonyl unit to nucleophiles such as amines and alcohols, forming sulfonamides and sulfonate esters. It is applied in C-S and C-X (non-halogen) bond formation and in benzotriazole-mediated methodology.
What is the CAS number and molecular formula of 1-(3-Pyridinylsulfonyl)-1H-benzotriazole?
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Its CAS number is 678173-43-8 and its molecular formula is C11H8N4O2S, with a molecular weight of 260.27 g/mol. The MDL number is MFCD05149210, and the reported melting point is 136-140 °C.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound at 95% assay as a research/reagent grade material. We do not represent it as USP, BP or EP pharmacopoeial grade. A specification or certificate of analysis can be provided on request to confirm assay and identity for your application.
What are the safety and handling precautions for this reagent?
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It carries GHS07 with the signal word Warning. The hazard statements are H302 (harmful if swallowed), H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and an N95-type dust mask, avoid dust formation, and follow P261 and P305+P351+P338. It is classified WGK 3 (German water hazard class); prevent release to water. Always consult the Safety Data Sheet before use.
Is 1-(3-Pyridinylsulfonyl)-1H-benzotriazole a controlled or scheduled substance?
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The supplied data does not indicate any drug-control, scheduling or precursor-control status for this compound. It is offered as a standard research chemical. Customers remain responsible for confirming compliance with the import, handling and end-use regulations in their own jurisdiction.
How is 1-(3-Pyridinylsulfonyl)-1H-benzotriazole packed, shipped and exported?
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It is packed as a solid in appropriately sized, tightly sealed containers with full labelling and accompanying documentation, and dispatched to suit research and bulk requirements. As a specialist exporter since 1998, Tech Serve Solutions arranges compliant international shipping with the relevant SDS and export paperwork.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, intended purity and delivery destination, and our team will respond with availability, lead time and a quotation. Samples can be discussed for qualified research and evaluation purposes.
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