1,3-Propanedithiol
1,3-Propanedithiol (CAS: 109-80-8), also known as HS(CH2)3SH, is a thiol compound with a molecular weight of 108.23 g/mol. This colourless liquid serves as a valuable building block in organic synthesis. Its dithiolic nature makes it particularly useful in materials science and micro/nanoelectronics for applications involving self-assembly and surface modification.
- IUPAC
- 1,3-Dimercaptopropane,Trimethylene dimercaptan
- Synonyms
- 1,3-DimercaptopropaneTrimethylene dimercaptan

Organic Synthesis Building Block
1,3-Propanedithiol acts as a difunctional reagent in organic synthesis, enabling the creation of cyclic and linear sulfur-containing compounds. It is often employed in protection/deprotection strategies for carbonyl compounds.
Materials Science
This dithiol is utilized in materials science for surface functionalization and the creation of self-assembled monolayers (SAMs) on various substrates, including gold. It facilitates controlled surface properties for advanced applications.
Micro/Nanoelectronics
In micro- and nanoelectronics, 1,3-Propanedithiol is used in fabricating nanoscale devices and conductive patterns through self-assembly techniques. Its ability to form ordered layers is crucial for precise engineering.
Polymer Chemistry
It can be incorporated into polymer structures to introduce sulfur functionalities, influencing polymer properties such as thermal stability and refractive index. It is also used in specific polymerization reactions.
| Molecular weight | 108.23 |
|---|---|
| Linear formula | HS(CH2)3SH |
| Assay | 99% |
| Boiling point | 169 °C(lit.) |
| Density | 1.078 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.539(lit.) |
| Vapour pressure | 5 mmHg (37.7 °C) |
| Melting point | −79 °C(lit.) |
| Vapour density | >1 (vs air) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 61 °C / 141.8 °F |
| Transport (UN / ADR) | UN 3334 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,3-Propanedithiol used for?
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1,3-Propanedithiol is primarily used as a building block in organic synthesis, for materials science applications like creating self-assembled monolayers, and in micro/nanoelectronics for surface modification and device fabrication. It is also employed in polymer chemistry.
What is the CAS number and formula for 1,3-Propanedithiol?
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The CAS number for 1,3-Propanedithiol is 109-80-8, and its linear formula is HS(CH2)3SH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,3-Propanedithiol with an assay of 99%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product documentation.
How should 1,3-Propanedithiol be handled safely?
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1,3-Propanedithiol is a warning-level chemical (GHS07) that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields and gloves, must be worn. Ensure adequate ventilation or use a suitable respirator.
How is 1,3-Propanedithiol packed, shipped, and exported?
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1,3-Propanedithiol is carefully packed according to international shipping regulations to ensure safe transit. Tech Serve Solutions has extensive experience exporting chemicals globally to meet your research and industrial needs.
How can I request a sample or quote for 1,3-Propanedithiol?
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To request a sample or a quotation for 1,3-Propanedithiol, please contact our sales department through the website or by phone. We will respond promptly to your inquiry.
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