1,3-Propanediol
1,3-Propanediol (CAS 504-63-2), also known as Trimethylene glycol, is a colorless, viscous liquid with the molecular formula C3H8O2 and a molar mass of 76.09 g/mol. This diol serves as a versatile building block in organic synthesis and finds application as a solvent. Its chemical structure facilitates its use in polymerization reactions and as a synthon for various chemical transformations.
- IUPAC
- 1,3-Dihydroxypropane,Bio-PDO,PG,Trimethylene glycol
- Synonyms
- HO(CH2)3OH1,3-DihydroxypropaneBio-PDOPGTrimethylene glycol

Solvent for Thin Film Preparations
1,3-Propanediol is employed as a solvent in the preparation of thin films. Its properties allow for the even distribution of materials during deposition processes.
Epoxide Chemistry
This compound functions as a vinyl epoxide synthon and is a key reagent for epoxide ring-opening reactions. It facilitates the introduction of the propanediol unit into various molecular structures.
Polymerization Reagent
1,3-Propanediol is utilised in polymerisation reactions. Its difunctional nature allows it to act as a monomer or chain extender in the synthesis of polymers.
Organic Synthesis Building Block
As a valuable organic building block, it is used in the synthesis of natural products and other complex organic molecules. It offers a three-carbon diol unit for synthetic strategies.
| Molecular weight | 76.09 |
|---|---|
| Linear formula | HO(CH2)3OH |
| Assay | 98% |
| Boiling point | 214 °C/760 mmHg(lit.) |
| Density | 1.053 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.440(lit.) |
| Solubility | H2O: soluble |
| Melting point | −27 °C(lit.) |
| Vapour pressure | 0.8 mmHg (20 °C)9.8 mmHg (100 °C) |
| Viscosity | 52 cP(20 °C)(lit.) |
| Impurities tested | <0.1% water |
| Application | Solvent for thin film preparations.1 Vinyl epoxide synthon2 and reagent for epoxide ring-opening3 and polymerization reactions.4 Reagent for natural product syntheses.5 |

Hazard statements
- H315Causes skin irritation
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 38 |
| Anion traces | chloride (Cl-): <0.5 ppm |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,3-Propanediol used for?
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1,3-Propanediol is used as a solvent for thin film preparations, a vinyl epoxide synthon, a reagent for epoxide ring-opening and polymerisation reactions, and as a building block in natural product syntheses.
What is the CAS number and formula for 1,3-Propanediol?
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The CAS number for 1,3-Propanediol is 504-63-2 and its linear formula is HO(CH2)3OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,3-Propanediol with an assay of 98%. We do not represent this product as USP, EP, BP, or any pharmacopoeia grade.
What are the safety considerations for handling 1,3-Propanediol?
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1,3-Propanediol is classified as a GHS07 irritant, with the signal word 'Warning' and hazard statement H315 (Causes skin irritation). Recommended personal protective equipment includes eyeshields and gloves. Handle in a well-ventilated area.
How is 1,3-Propanediol typically packed and shipped?
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1,3-Propanediol is available for global export from Tech Serve Solutions. Specific packing and shipping details are provided upon request and in accordance with international regulations.
How can I request a quote or sample of 1,3-Propanediol?
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To request a quote or sample of 1,3-Propanediol, please contact our sales team through the website or by phone. Please specify the quantity and destination for accurate quotation.
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