(1,3-Dioxolan-2-ylmethyl)magnesium bromide solution
(1,3-Dioxolan-2-ylmethyl)magnesium bromide solution (CAS: 180675-22-3) is an organometallic reagent with the empirical formula C4H7BrMgO2 and a molecular weight of 191.31 g/mol. Supplied as a 0.5 M solution in THF, this Grignard reagent is a valuable tool in organic synthesis. Its primary application involves introducing the 1,3-dioxolan-2-ylmethyl moiety into organic molecules through nucleophilic addition reactions, facilitating the construction of complex carbon frameworks.
- Synonyms
- C4H7BrMgO2
Nucleophilic Addition
Serves as a Grignard reagent for nucleophilic addition to carbonyl compounds (aldehydes, ketones, esters) and other electrophiles. This allows for the formation of new carbon-carbon bonds and the introduction of the protected hydroxymethyl group.
Organic Synthesis Intermediate
Used in multi-step synthesis pathways where the 1,3-dioxolane group acts as a masked aldehyde or alcohol. The protecting group can be subsequently removed under acidic conditions to reveal the functional group.
Preparation of Specialty Chemicals
Applicable in the synthesis of various fine chemicals and pharmaceutical intermediates requiring specific functionalisation with a protected hydroxyl group.
| Molecular weight | 191.31 |
|---|---|
| Empirical formula | C4H7BrMgO2 |
| Boiling point | 65-67 °C |
| Density | 0.938 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-19-34-37-40 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (1,3-Dioxolan-2-ylmethyl)magnesium bromide solution used for?
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This compound is primarily used as a Grignard reagent in organic synthesis for nucleophilic addition reactions, enabling the introduction of the 1,3-dioxolan-2-ylmethyl moiety into organic molecules.
What is the CAS number and formula for (1,3-Dioxolan-2-ylmethyl)magnesium bromide solution?
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The CAS number is 180675-22-3, and the empirical formula is C4H7BrMgO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in THF. The specific assay is not stated as pharmacopoeia grade; it is suitable for research and chemical synthesis purposes. TSS does not represent this product as USP, BP, or EP grade.
How should (1,3-Dioxolan-2-ylmethyl)magnesium bromide solution be handled and stored?
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This reagent reacts violently with water and may form explosive peroxides. It is corrosive and can cause severe skin burns and eye damage, and may cause respiratory irritation. Handle under an inert atmosphere, wear appropriate personal protective equipment (gloves, goggles, face shield), and avoid contact with water and oxidising agents. Store in a cool, dry, well-ventilated area away from incompatible materials.
Is this product regulated as a controlled substance?
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The provided data does not indicate that (1,3-Dioxolan-2-ylmethyl)magnesium bromide solution is a controlled substance.
How is this chemical shipped and exported?
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This product is classified under UN 2924, Hazard Class 8 (Corrosive) with a subsidiary hazard of Class 3 (Flammable liquid), Packing Group II. It is shipped and exported in compliance with relevant dangerous goods regulations.
How can I request a sample or quote for this product?
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Please contact the Tech Serve Solutions sales team via our website or direct enquiry channels to request a sample or obtain a quotation for (1,3-Dioxolan-2-ylmethyl)magnesium bromide solution.
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