1,3-Dimethyl-8-phenylxanthine
1,3-Dimethyl-8-phenylxanthine (CAS 961-45-5), with a molecular weight of 256.26 g/mol and formula C13H12N4O2, is an off-white to light yellow crystalline solid. It is recognised as a bioactive small molecule and a potent antagonist of adenosine receptors, particularly A1 receptors with a Ki of 86 nM. This compound is a valuable tool in biochemical research, cell biology, and neuroscience for studying purinergic signaling pathways and membrane protein functions.
- IUPAC
- 8-Phenyltheophylline
- Synonyms
- 8-Phenyltheophylline
Adenosine Receptor Antagonist
This compound acts as a selective antagonist for adenosine receptors, notably exhibiting high affinity for A1 receptors (Ki = 86 nM). It is instrumental in research investigating the physiological roles of adenosine signaling in various biological systems, including the central nervous system.
Neuroscience Research Tool
As a modulator of adenosine receptors, 1,3-Dimethyl-8-phenylxanthine is employed in neuroscience to study neurotransmission and neuronal function. Its activity contributes to understanding pathways related to sleep, cognition, and neuroprotection.
Cell Signaling Studies
The compound serves as a biochemical reagent for probing cell signaling cascades involving purinergic receptors. It aids researchers in elucidating signal transduction pathways and cellular responses regulated by extracellular adenosine.
Membrane Protein Research
Utilised in the study of membrane proteins, specifically G protein-coupled receptors like adenosine receptors. This allows for a deeper understanding of receptor-ligand interactions and their downstream effects on cellular activity.
| Molecular weight | 256.26 |
|---|---|
| Empirical formula | C13H12N4O2 |
| Form | crystalline |
| Colour | off-white to light yellow |
| Solubility | H2O: slightly solubleaqueous base: moderately soluble (Solutions should be stored at 4 °C.)ethanol: moderately soluble (Solutions should be stored at 4 °C.) |
| Melting point | >300 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... ADORA1(134), ADORA2B(136), ADORA3(140)rat ... Adora1(29290), Adora2a(25369), Adora2b(29316) |
|---|---|
| Potency | 86 nM Ki for A1 receptors |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,3-Dimethyl-8-phenylxanthine used for?
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1,3-Dimethyl-8-phenylxanthine (CAS 961-45-5) is used in biochemical research, cell biology, and neuroscience as an antagonist for adenosine receptors, particularly A1 receptors, and for studying cell signaling and membrane protein functions.
What are the CAS number and formula for 1,3-Dimethyl-8-phenylxanthine?
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The CAS number for 1,3-Dimethyl-8-phenylxanthine is 961-45-5, and its molecular formula is C13H12N4O2.
What grade and purity does Tech Serve Solutions supply for 1,3-Dimethyl-8-phenylxanthine?
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Tech Serve Solutions supplies 1,3-Dimethyl-8-phenylxanthine as a crystalline solid with a specified purity/assay that meets research-grade standards. It is not represented as USP, BP, EP, or pharmacopoeia grade.
What are the safety and handling recommendations for 1,3-Dimethyl-8-phenylxanthine?
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Appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter, should be used when handling 1,3-Dimethyl-8-phenylxanthine. It has a WGK Germany rating of 3.
How is 1,3-Dimethyl-8-phenylxanthine packed, shipped, and exported?
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1,3-Dimethyl-8-phenylxanthine is carefully packed to ensure stability and integrity during transit. Tech Serve Solutions, a global supplier, exports this chemical worldwide in compliance with international shipping regulations.
How can I request a sample or quote for 1,3-Dimethyl-8-phenylxanthine?
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To request a sample or a quotation for 1,3-Dimethyl-8-phenylxanthine, please contact the Tech Serve Solutions sales department via our website or direct inquiry channels.
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