1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CAS 4004-05-1C41H78NO8PBiochemicals & Reagents

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (CAS: 4004-05-1) is a glycerophospholipid with the empirical formula C41H78NO8P and a molecular weight of 744.03 g/mol. This compound is primarily utilised in biochemical research and cell biology studies. It is known for its role in forming liposomes, which serve as effective delivery vehicles for therapeutic agents when combined with specific cationic lipids.

IUPAC: (9Z)-9-Octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester,1,2-Di(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine,3-sn-Phosphatidylethanolamine, 1,2-dideoyl,L-β,γ-Dioleoyl-α-cephalin,DOPE,Dioleoyl phosphatidylethanolamine,PE(18:1(9Z)/18:1(9Z))
Synonyms: C41H78NO8P1,2-Dioleoyl-PEDioleoyl phosphatidylethanolamineDOPE

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1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (C41H78NO8P) — chemical structure, CAS 4004-05-1; Life Science, fine chemical supplied by Tech Serve Solutions

Biochemicals and ReagentsCell BiologyGlycerophospholipidsLipidsMetabolic PathwaysMetabolomics More...

01 /Applications

Liposome Formulation

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is a key component in the formation of liposomes. These vesicles can be formulated with cationic lipids like DOTAP to create delivery systems for therapeutic agents.

Drug Delivery Systems

Liposomes incorporating DOPE act as advanced delivery vehicles, facilitating the transport of various therapeutic compounds within biological systems. Their structure allows for encapsulation and controlled release.

Biochemical Research

As a glycerophospholipid, DOPE is valuable in studies related to cell membrane structure, lipid metabolism, and general biochemical investigations. It aids in understanding complex biological pathways.

Cell Biology Studies

This compound supports research in cell biology, particularly in understanding the function and dynamics of cell membranes and lipid-related cellular processes.

02 /Properties

Molecular weight	744.03
Empirical formula	C41H78NO8P
Assay	≥98.0% (TLC)
Storage temperature	−20°C
Application	1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) forms heterogenous liposomes with N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which are used as delivery vehicles for therapeutic agents 1.

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H336May cause drowsiness or dizziness
H351Suspected of causing cancer
H361D
H373May cause damage to organs through prolonged exposure

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)
Transport (UN / ADR)	UN 1888 6.1 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22-38-40-48/20/22
Safety statements (S)	36/37

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

4004-05-1

MDL number

MFCD00057986

Beilstein registry

1718431

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine used for?

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is used in biochemical research and cell biology, notably for forming liposomes that serve as delivery vehicles for therapeutic agents.

What are the CAS number and formula for this compound?

The CAS number is 4004-05-1, and the empirical formula is C41H78NO8P.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine with an assay of ≥98.0% (TLC). We do not represent this product as USP, BP, or EP grade.

What are the safety and handling precautions for this chemical?

This compound carries a Warning signal word and has hazard statements including H302 + H332 (Harmful if swallowed or inhaled), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H336 (May cause drowsiness or dizziness), H351 (Suspected of causing cancer), H361d (Suspected of damaging the unborn child), and H373 (May cause damage to organs through prolonged or repeated exposure). Appropriate personal protective equipment, including eyeshields, face shields, and gloves, should be used. Handle in a well-ventilated area or with respiratory protection.

How is this product typically packed and shipped?

This chemical is stored at -20°C. It is exported globally by Tech Serve Solutions, following all necessary shipping regulations for hazardous materials.