1,1′-Bis(di-tert-butylphosphino)ferrocene
1,1′-Bis(di-tert-butylphosphino)ferrocene (CAS: 84680-95-5) is a valuable organometallic compound with the empirical formula C26H44FeP2 and a molecular weight of 474.42 g/mol. As a polydentate phosphine ligand, it plays a crucial role in facilitating various catalytic transformations. Its primary applications lie in promoting reactions such as arylations, cross-coupling, and cycloadditions, making it an essential reagent in modern synthetic chemistry.
- IUPAC
- 1,1′-Bis(di-tert-butylphosphino)ferrocene,DBtPF
- Synonyms
- C26H44FeP2DBtPF
Catalysis in Organic Synthesis
This ferrocene-based phosphine ligand is instrumental in numerous transition metal-catalyzed reactions. It effectively facilitates arylations and is a key component in Suzuki-Miyaura coupling reactions, enabling the formation of carbon-carbon bonds.
Cross-Coupling Reactions
The ligand is widely employed in Buchwald-Hartwig cross-coupling reactions, a powerful method for forming carbon-nitrogen and carbon-oxygen bonds. Its unique structure contributes to high catalytic activity and selectivity in these processes.
Cycloaddition and Carbonyl Insertion
1,1′-Bis(di-tert-butylphosphino)ferrocene participates in cycloaddition reactions and promotes carbonyl insertion processes. It also aids in reduction and deoxygenation transformations, expanding its utility in complex molecule synthesis.
Indole Forming Reactions
This compound serves as an effective ligand in catalytic systems designed for the synthesis of indole derivatives, which are important structural motifs in pharmaceuticals and natural products.
| Molecular weight | 474.42 |
|---|---|
| Empirical formula | C26H44FeP2 |
| Application | Form the diene complexation; carbonyl insertion; cycloaddition; reduction and deoxygenation. |
| Melting point | 73-75 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Ligand For | ArylationsBuchwald-Hartwig Cross Coupling ReactionIndole Forming ReactionsSuzuki-Miyaura Coupling |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,1′-Bis(di-tert-butylphosphino)ferrocene used for?
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1,1′-Bis(di-tert-butylphosphino)ferrocene is primarily used as a ligand in various catalytic applications, including arylations, Buchwald-Hartwig cross-coupling, Suzuki-Miyaura coupling, indole forming reactions, carbonyl insertion, cycloaddition, reduction, and deoxygenation.
What is the CAS number and formula for 1,1′-Bis(di-tert-butylphosphino)ferrocene?
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The CAS number for 1,1′-Bis(di-tert-butylphosphino)ferrocene is 84680-95-5, and its empirical formula is C26H44FeP2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,1′-Bis(di-tert-butylphosphino)ferrocene typically as a research or technical grade chemical. We do not represent this product as meeting USP, BP, or EP pharmacopoeia standards unless explicitly stated.
What are the safety and handling precautions for this chemical?
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This compound is classified as a Warning. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be worn. Handle in a well-ventilated area.
How is 1,1′-Bis(di-tert-butylphosphino)ferrocene packed, shipped, and exported?
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1,1′-Bis(di-tert-butylphosphino)ferrocene is carefully packed according to international shipping regulations and is available for global export by Tech Serve Solutions.
How can I request a sample or quote for 1,1′-Bis(di-tert-butylphosphino)ferrocene?
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To request a sample or a quote, please contact our sales department via the website or directly by phone, providing the product name and CAS number.
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