1,1,3,3-Tetramethylguanidine
1,1,3,3-Tetramethylguanidine (CAS 80-70-6), a colourless to pale yellow liquid with the molecular formula C5H13N3 and a molar mass of 115.18 g/mol, is a strong organic base. It is primarily utilised as a catalyst and a reagent in various chemical syntheses. Its applications include the preparation of alkyl nitriles from alkyl halides and the synthesis of 3′-alkylthymidines. This guanidine derivative is essential for specific organic transformations.
- IUPAC
- N,N,N′,N′-Tetramethylguanidine
- Synonyms
- 3-TetramethylguanidineN,N,N′,N′-Tetramethylguanidine
Organic Synthesis Reagent
1,1,3,3-Tetramethylguanidine serves as a strong, non-nucleophilic base in organic synthesis. It is employed in reactions such as the preparation of alkyl nitriles from alkyl halides and the synthesis of specialized nucleosides.
Catalysis
This compound can function as a catalyst in certain organic reactions. Its basic nature facilitates various chemical transformations where a strong base is required.
Building Block
As an organic building block, it can be incorporated into more complex molecular structures. Its guanidine functionality offers specific reactivity for constructing diverse chemical entities.
| Molecular weight | 115.18 |
|---|---|
| Linear formula | (CH3)2NC(=NH)N(CH3)2 |
| Assay | 99% |
| Boiling point | 52-54 °C/11 mmHg(lit.) |
| Density | 0.918 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.469(lit.) |
| Vapour pressure | 0.2 mmHg (20 °C) |
| Impurities tested | ≤0.50% water |
| Application | Base employed in the preparation of alkyl nitriles from alkyl halides and 3′-alkylthymidines from 3′-nitrothymidines. |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 60 °C / 140 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | C |
| Risk statements (R) | 22-34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... EPHX2(2053)mouse ... Ephx2(13850) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,1,3,3-Tetramethylguanidine used for?
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1,1,3,3-Tetramethylguanidine is used as a base in organic synthesis, for example, in the preparation of alkyl nitriles from alkyl halides and 3′-alkylthymidines from 3′-nitrothymidines.
What is the CAS number and chemical formula for 1,1,3,3-Tetramethylguanidine?
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The CAS number is 80-70-6 and the chemical formula is C5H13N3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,1,3,3-Tetramethylguanidine with an assay of 99% and containing ≤0.50% water. TSS does not represent this product as USP, BP, or EP grade.
How should 1,1,3,3-Tetramethylguanidine be handled safely?
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1,1,3,3-Tetramethylguanidine is classified as a Danger hazard. It is flammable and causes severe skin burns and eye damage. Handle with appropriate personal protective equipment, including full-face respirators, chemical-resistant gloves, and eye protection, in a well-ventilated area. Refer to the Safety Data Sheet for full details.
How is 1,1,3,3-Tetramethylguanidine packed and shipped?
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1,1,3,3-Tetramethylguanidine is packed and shipped according to relevant transport regulations for hazardous materials, such as UN 2920, Class 3(8), Packing Group II.
How can I request a quote or sample of 1,1,3,3-Tetramethylguanidine?
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To request a quote or sample, please contact our sales department through the TSS website or by phone, providing the product name and CAS number.
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