Zardaverine
Zardaverine (CAS: 101975-10-4) is a fluorinated organic compound with the molecular formula C12H10F2N2O3 and a molecular weight of 268.22 g/mol. This molecule acts as a potent inhibitor of phosphodiesterase enzymes, specifically targeting PDE III and PDE IV. Its primary applications lie in biochemical research, particularly in studies related to cell signaling, cyclic nucleotide metabolism, and enzyme inhibition. Zardaverine serves as a valuable tool for researchers investigating these pathways.
- IUPAC
- 6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone
Phosphodiesterase Inhibition
Zardaverine is a selective inhibitor of phosphodiesterase (PDE) enzymes, with documented IC50 values for PDE IV (1.1 μM) and PDE III (2.5 μM). This makes it a useful research chemical for studying the roles of these enzymes in cellular processes.
Cell Signaling Research
As an inhibitor of PDE enzymes, Zardaverine can modulate intracellular levels of cyclic nucleotides like cAMP and cGMP. This makes it a valuable tool for researchers investigating signal transduction pathways and cellular responses.
Biochemical and Biomedical Studies
The compound is employed in various biochemical and biomedical research settings to explore the functions of PDE isozymes and their involvement in physiological and pathological processes, including neuroscience and cell biology.
| Molecular weight | 268.22 |
|---|---|
| Empirical formula | C12H10F2N2O3 |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Potency | 1.1 μM IC50 (for PDE IV)2.5 μM IC50 (for PDE III) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Zardaverine used for?
+
Zardaverine is primarily used as a research chemical for its inhibitory activity against phosphodiesterase (PDE) enzymes, particularly PDE IV and PDE III. It is valuable in studies of cell signaling, cyclic nucleotide metabolism, and related biochemical pathways.
What is the CAS number and chemical formula for Zardaverine?
+
The CAS number for Zardaverine is 101975-10-4, and its empirical formula is C12H10F2N2O3.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Zardaverine typically as a research or technical grade chemical. The specific purity and assay are available on the product's Certificate of Analysis. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
What are the safety precautions for handling Zardaverine?
+
When handling Zardaverine, it is essential to use appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if airborne exposure is possible. The compound has a WGK Germany rating of 3, indicating a high hazard potential.
How is Zardaverine packed and shipped?
+
Zardaverine is carefully packed and prepared for export by Tech Serve Solutions, adhering to all necessary regulations for the safe and secure transport of fine chemicals globally.
How can I request a quote or sample for Zardaverine?
+
To request a quote or a sample of Zardaverine, please contact our sales team through the website or by directly calling our office. Provide the product name and CAS number (101975-10-4) for prompt service.
▶ Related products
![(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (C8H13N3O4) — chemical structure, CAS 138472-01-2; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F138472-01-2.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
C8H13N3O4
Biochemicals & Reagents![(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide (C14H18N4O4) — chemical structure, CAS 162626-99-5; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F162626-99-5.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide
C14H18N4O4
Biochemicals & Reagents
(±)-2,5-Dimethoxy-4-bromoamphetamine hydrobromide
Biochemicals & Reagents
(±)-2-(p-Methoxyphenoxy)propionic acid
C10H12O4
Biochemicals & Reagents
(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide
C10H13NO2·HBr
Biochemicals & Reagents
(±)-2-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxyoctanoic acid
C8H16O3
Biochemicals & Reagents▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis