U-73122 hydrate
U-73122 hydrate (CAS: 112648-68-7) is a chemical compound with the formula C29H40N2O3 · xH2O and a molecular weight of 464.64 (anhydrous basis). Supplied by Tech Serve Solutions as an off-white powder, it functions as an inhibitor of phospholipase C (PLC) signaling. This makes it valuable for scientific research, particularly in studying cellular signaling pathways, ion channel function, and local calcium responses in various cell types.
- IUPAC
- 1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-1H-pyrrole-2,5-dione
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Phospholipase C (PLC) Inhibition
U-73122 hydrate is utilized in research to inhibit phospholipase C (PLC) signaling pathways. This allows scientists to investigate the downstream effects of PLC activation in cellular processes.
Cellular Signaling Studies
The compound has been employed in studies examining the role of PLC signaling in modulating epithelial Na+ channel (ENaC) function. It aids in understanding complex cellular communication networks.
Calcium Response Research
U-73122 hydrate has been used to study local calcium responses in human umbilical vein endothelial cells (HUVECs), contributing to research in cardiovascular and cellular physiology.
| Molecular weight | 464.64 (anhydrous basis) |
|---|---|
| Empirical formula | C29H40N2O3 · xH2O |
| Form | powder |
| Colour | off-white |
| Solubility | ethanol: ~.7 mg/mLDMSO: ~.9 mg/mLchloroform: ~10 mg/mLDMSO: ≤2.6 mg/mL (Achieved with heating.)ethanol: ≤5 mg/mL (Achieved with heating.)H2O: insoluble |
| Storage temperature | room temp |
| Application | U-73122 hydrate has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na+ channel (ENaC) function in gerbil Reissner′s membranes (RMs)1. U-73122 has also been used to study local calcium responses in human umbilical vein endothelial cells (HUVECs)2. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is U-73122 hydrate used for?
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U-73122 hydrate is used in scientific research as an inhibitor of phospholipase C (PLC) signaling, for studying cellular signaling pathways, epithelial Na+ channel function, and local calcium responses.
What is the CAS number and formula for U-73122 hydrate?
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The CAS number for the anhydrous form is 112648-68-7. The empirical formula is C29H40N2O3 · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies U-73122 hydrate as a research-grade chemical. The assay is not specified, and it is not represented as USP, BP, EP, or any pharmacopoeia grade.
How should U-73122 hydrate be handled safely?
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U-73122 hydrate is classified with a Warning signal word and carries hazard statements H315, H319, and H335. Handle with appropriate personal protective equipment including a dust mask (N95 US), eyeshields, and gloves. Avoid dust formation and ensure adequate ventilation.
How is U-73122 hydrate packed, shipped, and exported?
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U-73122 hydrate is typically supplied in standard laboratory packaging suitable for powders. Tech Serve Solutions is a global supplier and exporter, adhering to all relevant regulations for the shipment of chemical compounds.
How can I request a sample or quote for U-73122 hydrate?
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To request a sample or quote for U-73122 hydrate, please contact the Tech Serve Solutions sales team through the website or by phone, providing your specific requirements.
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