Tyrphostin AG 1295
Tyrphostin AG 1295 (CAS: 71897-07-9) is a bioactive small molecule with the chemical formula C16H14N2 and a molecular weight of 234.30 g/mol. This compound functions as an enzyme inhibitor, particularly targeting receptor tyrosine kinases. It is valuable in biological research for studying cell signaling pathways, cell division, and DNA synthesis, offering insights into cellular processes affected by growth factors like PDGFR.
- IUPAC
- 6,7-Dimethyl-2-phenylquinoxaline
Flt3 Inhibition Studies
Tyrphostin AG 1295 has been utilised as an inhibitor of Flt3 in progenitor cell lines, such as NA10 and ND13, aiding research into haematopoietic stem cell development and related disorders.
Nicotine-Induced Cell Effects
Research has employed AG 1295 to investigate the impact of nicotine on human aortic vascular smooth muscle cells, demonstrating its role in reducing cell division and DNA synthesis influenced by this substance.
Receptor Tyrosine Kinase Research
As an inhibitor of receptor tyrosine kinases like PDGFR, Tyrphostin AG 1295 is a key reagent for elucidating signalling cascades and cellular responses mediated by these critical enzymes in various biological contexts.
| Molecular weight | 234.30 |
|---|---|
| Empirical formula | C16H14N2 |
| Assay | ≥98% |
| Solubility | 0.1 M HCl: soluble ethanol: soluble10 mg/mLmethylene chloride: soluble10 mg/mL0.1 M NaOH: insoluble2-hydroxypropyl-β-cyclodextrin: insolubleH2O: insoluble |
| Storage temperature | −20°C |
| Application | Tyrphostin AG 1295 has been used as an Flt3 inhibitor in NA10 and ND13 progenitor cell lines2. Studies using AG 1295 have reported that it can reduce cell division and DNA synthesis induced by nicotine in human aortic vascular smooth muscle cells3. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... EGFR(1956), FLT3(2322), PDGFRB(5159), SRC(6714)mouse ... Pdgfrb(18596) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tyrphostin AG 1295 used for?
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Tyrphostin AG 1295 is used in research as an inhibitor of receptor tyrosine kinases, particularly Flt3 and PDGFR. It aids in studying cell division, DNA synthesis, and cellular responses in various cell lines and models.
What is the CAS number and formula for Tyrphostin AG 1295?
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The CAS number for Tyrphostin AG 1295 is 71897-07-9, and its chemical formula is C16H14N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tyrphostin AG 1295 with an assay of ≥98%. We do not represent this product as USP, BP, or EP grade.
How should Tyrphostin AG 1295 be handled safely?
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Appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter, should be used when handling Tyrphostin AG 1295. Dispose of waste in accordance with local regulations.
How is Tyrphostin AG 1295 packed and shipped?
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Tyrphostin AG 1295 is typically stored at -20°C. We ensure appropriate packaging for domestic and international export, adhering to all regulatory requirements for chemical shipments.
How can I request a quote or sample for Tyrphostin AG 1295?
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To request a quote or sample of Tyrphostin AG 1295, please visit the Tech Serve Solutions website or contact our sales team directly with your inquiry.
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