Trichostatin A

CAS 58880-19-6C17H22N2O3Biochemicals & Reagents

Trichostatin A (TSA), CAS 58880-19-6, with the molecular formula C17H22N2O3 and a molecular weight of 302.37, is a potent histone deacetylase (HDAC) inhibitor. Derived from Streptomyces sp., it is utilised in various biological research applications, including the study of cloned mouse embryos and as an experimental tool in cancer cell lines like LNCaP, MON, and HeLa for investigating epigenetic mechanisms. This PREMIUM grade chemical is essential for advanced molecular biology research.

IUPAC: TSA,[R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

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Trichostatin A (C17H22N2O3) — chemical structure, CAS 58880-19-6; Life Science, fine chemical supplied by Tech Serve Solutions

Antitumor AgentsBioactive Small MoleculesBiochemicals and ReagentsCancer ResearchCell BiologyD to KEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitors

01 /Applications

Epigenetic Research

Trichostatin A functions as a histone deacetylase (HDAC) inhibitor, making it invaluable for studying epigenetic modifications. It has been employed in research involving cloned mouse embryos and various cancer cell lines to investigate gene expression regulation.

Cancer Research

Utilised in cancer research, TSA has been applied to human prostate cancer cells (LNCaP) and other cell lines (MON, HeLa) to explore the role of HDAC inhibition in cellular processes relevant to oncogenesis and potential therapeutic strategies.

Cell Biology Studies

TSA serves as a critical reagent in cell biology for probing cellular signalling pathways and mechanisms. Its ability to inhibit HDACs impacts gene transcription, cell differentiation, and cell cycle progression, facilitating fundamental biological investigations.

02 /Properties

Molecular weight	302.37
Empirical formula	C17H22N2O3
Assay	≥98% (HPLC)
Solubility	methanol: soluble1.90 - 2.10 mg/mL, clear, colorless to faint yellow or tanDMF: solubleDMSO: solubleH2O: insolubleacetone: slightly solubleacetonitrile: solublebenzene: slightly solublechloroform: slightly solubleethanol: solubleethyl acetate: slightly solublelower alcohols: soluble
Storage temperature	−20°C
Application	Trichostatin A (TSA) has been used during the production of cloned mouse embryos1. TSA has also been used as a histone deacetylase (HDAC) inhibitor in LNCaP human prostate cancer cells2, as well as in MON and HeLa cells3.
Biological source	from Streptomyces sp.

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P280Wear protective gloves, clothing and eye/face protection
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	20/21/22-36/37/38-43
Safety statements (S)	26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

58880-19-6

MDL number

MFCD03848392

PubChem substance

24900542

05 /Additional specifications

Quality Level	PREMIUM
Gene Information	human ... HDAC1(3065), HDAC4(9759), HDAC6(10013), HDAC8(55869)mouse ... ENSMUSG00000061062(15181)rat ... Hdac7a(84582)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Trichostatin A used for?

Trichostatin A (TSA) is primarily used as a histone deacetylase (HDAC) inhibitor in research settings. It has applications in epigenetics, cancer research, cell biology, and studies involving cloned mouse embryos. It is not for human or veterinary use.

What are the CAS number and formula for Trichostatin A?

The CAS number for Trichostatin A is 58880-19-6, and its empirical formula is C17H22N2O3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Trichostatin A at a PREMIUM quality level with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.

How should Trichostatin A be handled safely?

Trichostatin A is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation. It may also cause respiratory irritation and allergic skin reactions. Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, face shield, and gloves, in a well-ventilated area.

Is Trichostatin A a controlled substance?

The provided data does not indicate that Trichostatin A is a controlled substance.

How is Trichostatin A shipped and exported?

Trichostatin A is typically stored at -20°C. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and can arrange for appropriate shipping and export documentation as per regulatory requirements.