(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate
(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate is a chemical compound supplied by Tech Serve Solutions. Identified by CAS number 114528-79-9 (anhydrous), this substance has a molecular weight of 405.79 g/mol on an anhydrous basis. Its primary application is as a κ-opioid receptor (KOR) agonist, utilized in research to investigate its physiological effects. It is supplied as a white solid.
- IUPAC
- trans-(1S,2S)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride hydrate
- Synonyms
- trans-(1S,2S)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride hydrate
-U-50488hydrochloridehydrate.png&w=3840&q=75)
κ-Opioid Receptor (KOR) Agonist
This compound acts as a selective agonist for the kappa-opioid receptor (KOR). It is employed in scientific research to explore the role of KOR signalling in various physiological processes and to study its downstream effects.
Research in Neurobiology and Pharmacology
Used as a tool compound in neuroscience and pharmacology research, particularly in studies involving pain perception, mood regulation, and addiction mechanisms. Its selectivity for KOR makes it valuable for dissecting specific receptor pathways.
Investigation of Respiratory Effects
Has been utilised in studies to examine its impact on respiratory function, such as its effect on tidal volumes in animal models, providing insights into opioid-mediated respiratory control.
| Molecular weight | 405.79 (anhydrous basis) |
|---|---|
| Empirical formula | C19H26Cl2N2O · HCl · xH2O |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | white |
| Solubility | H2O: soluble13 mg/mL |
| Optical activity | [α]22/D −36.05°, c = 0.73 in methanol(lit.) |
| Storage temperature | 2-8°C |
| Application | (−)-trans-(1S,2S)-U-50488 hydrochloride hydrate (U-50488) has been used as a κ-opioid receptor (KOR) agonist has been used to study its effect on the increase of tidal volumes in adult red-eared slider turtles (Trachemys scripta)1. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... OPRK1(4986) |
|---|---|
| Storage Condition | desiccated |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (–)-trans-(1S,2S)-U-50488 hydrochloride hydrate used for?
+
It is primarily used as a selective kappa-opioid receptor (KOR) agonist in research settings, particularly within neurobiology and pharmacology, to study its effects on various physiological processes, including respiratory function.
What are the CAS number and molecular formula?
+
The CAS number for the anhydrous form is 114528-79-9. The empirical formula is C19H26Cl2N2O · HCl · xH2O.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this compound with an assay of ≥98% (HPLC). We do not represent it as USP, BP, or EP grade.
How should (–)-trans-(1S,2S)-U-50488 hydrochloride hydrate be handled?
+
Handling requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter, due to its classification with WGK Germany 3.
How is this chemical packed, shipped, and exported?
+
This compound is typically supplied as a white solid and stored under desiccated conditions at 2-8°C. Tech Serve Solutions is a global supplier and exporter of fine chemicals.
How can I request a sample or quote for (–)-trans-(1S,2S)-U-50488 hydrochloride hydrate?
+
Please contact our customer service team through our website or by phone to request a sample or a quotation.
▶ Related products
![(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (C8H13N3O4) — chemical structure, CAS 138472-01-2; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F138472-01-2.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
C8H13N3O4
Biochemicals & Reagents![(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide (C14H18N4O4) — chemical structure, CAS 162626-99-5; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F162626-99-5.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide
C14H18N4O4
Biochemicals & Reagents
(±)-2,5-Dimethoxy-4-bromoamphetamine hydrobromide
Biochemicals & Reagents
(±)-2-(p-Methoxyphenoxy)propionic acid
C10H12O4
Biochemicals & Reagents
(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide
C10H13NO2·HBr
Biochemicals & Reagents
(±)-2-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxyoctanoic acid
C8H16O3
Biochemicals & Reagents▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis