Tolmetin sodium salt dihydrate
Tolmetin sodium salt dihydrate (CAS: 64490-92-2) is a sodium salt of tolmetin, a non-steroidal anti-inflammatory drug (NSAID). This compound is formulated as a dihydrate, with the chemical formula C15H14NO3Na · 2H2O and a molecular weight of 315.30 g/mol. It is recognised for its ability to circumvent MRP-mediated multidrug resistance and enhance the cytotoxicity of certain chemotherapy agents, making it valuable in research applications related to drug resistance and cancer therapeutics.
- IUPAC
- 1-Methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium salt dihydrate
- Synonyms
- 1-Methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium salt dihydrate
Modulation of Multidrug Resistance
Tolmetin sodium salt dihydrate serves as a research tool to investigate and circumvent multidrug resistance (MDR) mediated by MRP transporters. It has demonstrated effectiveness in overcoming resistance mechanisms in cellular models.
Chemotherapeutic Agent Sensitizer
This compound significantly potentiates the cytotoxic effects of various chemotherapy drugs, including anthracyclines (doxorubicin, daunorubicin, epirubicin), teniposide, VP-16, and vincristine, in preclinical research settings.
NSAID Research
As a derivative of tolmetin, it can be utilised in studies focused on the mechanisms of action and pharmacological properties of non-steroidal anti-inflammatory drugs.
| Molecular weight | 315.30 |
|---|---|
| Linear formula | C15H14NO3Na · 2H2O |
| Solubility | H2O: soluble50 mg/mL, clear, colorless |
| Application | An NSAID. Circumvents MRP-mediated multidrug resistance. Significantly increases the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine. |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-38 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tolmetin sodium salt dihydrate used for?
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Tolmetin sodium salt dihydrate is used in research for its ability to circumvent MRP-mediated multidrug resistance and to potentiate the cytotoxicity of certain chemotherapy agents. It also has applications in NSAID research.
What is the CAS number and formula for Tolmetin sodium salt dihydrate?
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The CAS number is 64490-92-2 and the chemical formula is C15H14NO3Na · 2H2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tolmetin sodium salt dihydrate. The specific grade and purity are detailed in the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade unless explicitly stated in the specifications.
What are the safety and handling considerations for this product?
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Tolmetin sodium salt dihydrate is classified with GHS07 symbol and 'Warning' signal word. It is labelled with H302 (Harmful if swallowed) and H315 (Causes skin irritation) hazard statements. Handle with appropriate personal protective equipment in a well-ventilated area.
How is Tolmetin sodium salt dihydrate packed, shipped, and exported?
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Tech Serve Solutions packs and ships chemicals according to international regulations, ensuring safe transit. As a global supplier, we handle export logistics for researchers and institutions worldwide.
How can I request a sample or quote for Tolmetin sodium salt dihydrate?
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To request a sample or a quotation, please contact our sales team via the website or by phone, providing the product name and CAS number (64490-92-2).
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