tert-Butylmagnesium chloride solution
tert-Butylmagnesium chloride solution (CAS: 677-22-5; Molecular Weight: 116.87) is a highly reactive organometallic compound, commonly supplied as a 1.0 M solution in Tetrahydrofuran (THF). As a Grignard reagent, it is a powerful nucleophile and a strong base, extensively employed in organic synthesis for carbon-carbon bond formation and the introduction of tert-butyl groups into various organic molecules. It is vital in the preparation of complex chemical structures.
Nucleophilic Addition Reactions
As a Grignard reagent, tert-Butylmagnesium chloride solution readily adds to carbonyl compounds such as aldehydes and ketones, forming tertiary alcohols. This is a fundamental transformation in organic chemistry for building complex molecular frameworks.
Carbon-Carbon Bond Formation
This reagent is instrumental in forming new carbon-carbon bonds by reacting with electrophilic carbon centers. It is widely used in the synthesis of pharmaceuticals, agrochemicals, and other fine organic chemicals.
Introduction of tert-Butyl Groups
tert-Butylmagnesium chloride solution serves as an efficient source for introducing the sterically bulky tert-butyl group into organic molecules. This moiety can significantly influence the physical and chemical properties of the final product.
Deprotonation Agent
Due to its strong basicity, it can be used as a non-nucleophilic base to deprotonate relatively acidic protons in organic substrates, facilitating various synthetic transformations.
| Molecular weight | 116.87 |
|---|---|
| Linear formula | (CH3)3CMgCl |
| Density | 0.931 g/mL at 25 °C |
| Concentration | 1.0 M in THF |
Hazard statements
- H225Highly flammable liquid and vapour
- H250Catches fire spontaneously if exposed to air
- H260In contact with water releases flammable gases
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P222Do not allow contact with air
- P223Do not allow contact with water
- P231Handle under inert gas
- P370In case of fire
- P422
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -17 °C / 1.4 °F |
| Transport (UN / ADR) | UN 3399 4.3/PG 1 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14/15-19-34-37 |
| Safety statements (S) | 16-26-36/37/39-43-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is tert-Butylmagnesium chloride solution used for?
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tert-Butylmagnesium chloride solution is primarily used in organic synthesis as a Grignard reagent for carbon-carbon bond formation, nucleophilic additions to carbonyls, and the introduction of tert-butyl groups. It also functions as a strong base for deprotonation reactions.
What is the CAS number and formula for tert-Butylmagnesium chloride solution?
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The CAS number for tert-Butylmagnesium chloride solution is 677-22-5, and its linear formula is (CH₃)₃CMgCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies tert-Butylmagnesium chloride solution at a concentration of 1.0 M in THF. We do not represent this product as USP, BP, EP, or for food/nutraceutical use.
How is tert-Butylmagnesium chloride solution handled and shipped?
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tert-Butylmagnesium chloride solution is a highly flammable liquid and vapour, causes severe skin burns and eye damage, and may react violently with water. It is pyrophoric and air and moisture sensitive. Shipments require specialised packaging and handling protocols. Please consult the Safety Data Sheet (SDS) for detailed safety information.
Is tert-Butylmagnesium chloride solution a controlled substance?
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This product is not listed as a controlled substance in typical international chemical control regulations.
How can I request a quote or sample?
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To request a quote or sample of tert-Butylmagnesium chloride solution, please contact our sales team through the website or by phone, providing the product name and CAS number (677-22-5).
Where can I find more information on the safety of tert-Butylmagnesium chloride solution?
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Detailed safety information, including hazard statements, precautionary statements, and required personal protective equipment, is available in the Safety Data Sheet (SDS) provided by Tech Serve Solutions.
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