Suberic acid bis(N-hydroxysuccinimide ester)
Suberic acid bis(N-hydroxysuccinimide ester), CAS 68528-80-3, with the molecular formula C16H20N2O8, is a homobifunctional cross-linking reagent. It features two N-hydroxysuccinimide ester groups spaced by an 8-atom linker, enabling it to react with primary amines. This compound is typically employed in chemical biology and organic synthesis for covalently linking molecules that possess amine functionalities.
- IUPAC
- Disuccinimidyl octanedioate,Disuccinimidyl suberate (DSS)
- Synonyms
- Disuccinimidyl octanedioateDisuccinimidyl suberate (DSS)
Homobifunctional Cross-linking
Utilised to covalently link molecules containing primary amine groups. The N-hydroxysuccinimide esters react with amines to form stable amide bonds, incorporating an 8-atom linker between the conjugated entities. This is often performed in buffered solutions around pH 7.5.
Protein Modification and Analysis
Applicable in protein chemistry for cross-linking amine residues, aiding in the study of protein structure and interactions. It can be used to stabilise protein complexes or to immobilise proteins for assays.
Bioconjugation Chemistry
Serves as a versatile reagent in bioconjugation, enabling the coupling of biomolecules such as proteins, peptides, or antibodies to other molecules or surfaces that present primary amines.
| Molecular weight | 368.34 |
|---|---|
| Empirical formula | C16H20N2O8 |
| Assay | ≥95% |
| Form | powder |
| Solubility | chloroform: soluble50 mg/mLDMF: solubleaqueous buffer: slightly soluble (may require 5-10% organic solvent in coupling mixture.) |
| Storage temperature | 2-8°C |
| Application | Homobifunctional cross-linking reagent with amine reactivity. Typically coupled to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). Incorporates 8-atom linker. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Suberic acid bis(N-hydroxysuccinimide ester) used for?
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Suberic acid bis(N-hydroxysuccinimide ester) is primarily used as a homobifunctional cross-linking reagent for covalently linking molecules containing primary amine groups, often in protein modification, bioconjugation, and chemical synthesis applications.
What is the CAS number and molecular formula?
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The CAS number is 68528-80-3, and the molecular formula is C16H20N2O8.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Suberic acid bis(N-hydroxysuccinimide ester) with an assay of ≥95%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or other pharmacopoeial grades.
How should Suberic acid bis(N-hydroxysuccinimide ester) be handled and stored?
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Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator filter. Store at 2-8°C to maintain stability. Refer to the safety data sheet for detailed handling procedures.
Is this chemical a controlled substance?
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The provided data does not indicate that Suberic acid bis(N-hydroxysuccinimide ester) is a controlled substance.
How is this product shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and this product can be shipped and exported internationally according to regulatory requirements.
How can I request a sample or quote?
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To request a sample or a quote for Suberic acid bis(N-hydroxysuccinimide ester), please contact the Tech Serve Solutions sales team through the website or designated contact channels.
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