(R)-(−)-1-(1-Naphthyl)ethyl isocyanate
(R)-(−)-1-(1-Naphthyl)ethyl isocyanate (CAS 42340-98-7), with the molecular formula C <sub>10</sub>H<sub>7</sub>CH(CH<sub>3</sub>)NCO and a molecular weight of 197.23, is a chiral isocyanate. It is predominantly utilized as a chiral derivatizing agent in asymmetric synthesis and for chiral resolution. Its specific optical activity and purity make it a valuable building block for creating enantiomerically pure compounds in research and development.
- IUPAC
- (R)-NEI
Chiral Derivatizing Agent
This compound serves as an effective chiral derivatizing agent. It reacts with chiral amines and alcohols to form diastereomeric derivatives, which can then be separated and analyzed by chromatography, aiding in the determination of enantiomeric purity.
Asymmetric Synthesis
As a chiral building block, (R)-(−)-1-(1-Naphthyl)ethyl isocyanate is employed in asymmetric synthesis to introduce chirality into target molecules, enabling the creation of enantiomerically enriched products.
Chiral Resolution
It is utilized in chiral resolution techniques to separate racemic mixtures into their individual enantiomers by forming diastereomeric salts or adducts with the target compounds.
| Molecular weight | 197.23 |
|---|---|
| Linear formula | C10H7CH(CH3)NCO |
| Assay | 98% |
| Boiling point | 106-108 °C/0.16 mmHg(lit.) |
| Density | 1.118 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.604(lit.) |
| Optical activity | [α]20/D −45°, c = 3.5 in toluene |
| Optical purity | ee: 95% (GLC) |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P342
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 93 °C / 199.4 °F |
| Transport (UN / ADR) | UN 2206 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 36/37/38-42/43 |
| Safety statements (S) | 23-26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(−)-1-(1-Naphthyl)ethyl isocyanate primarily used for?
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It is primarily used as a chiral derivatizing agent in asymmetric synthesis and for chiral resolution to determine and achieve enantiomeric purity.
What are the CAS number and molecular formula for (R)-(−)-1-(1-Naphthyl)ethyl isocyanate?
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The CAS number is 42340-98-7 and the molecular formula is C <sub>10</sub>H<sub>7</sub>CH(CH<sub>3</sub>)NCO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of 98% and an optical purity of 95% ee (GLC). We do not represent it as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated.
What are the key safety concerns when handling (R)-(−)-1-(1-Naphthyl)ethyl isocyanate?
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This compound is classified as Danger, with hazards including toxicity if swallowed (H301), skin irritation (H315), skin sensitisation (H317), serious eye irritation (H319), and respiratory sensitisation (H334), as well as potential respiratory irritation (H335).
How is (R)-(−)-1-(1-Naphthyl)ethyl isocyanate packed, shipped, and exported?
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As a specialist global supplier and exporter, Tech Serve Solutions ensures appropriate packaging and adherence to all regulations for shipping and exporting this chemical, including UN 2206, Hazard Class 6.1, Packing Group III.
How can I request a sample or quote for (R)-(−)-1-(1-Naphthyl)ethyl isocyanate?
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Please contact our sales team through the website or by phone to request a sample or a quotation for (R)-(−)-1-(1-Naphthyl)ethyl isocyanate.
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