Nutlin-3a

CAS 675576-98-4C30H30Cl2N4O4Cell Biology

Nutlin-3a (CAS: 675576-98-4), a chemical compound with the formula C30H30Cl2N4O4 and a molecular weight of 581.49 g/mol, is a potent inhibitor of the MDM2-p53 interaction. This selective antagonist plays a crucial role in reactivating p53-mediated tumour suppression. Its primary applications lie in biochemical research, particularly in studies involving apoptosis, cell cycle regulation, and cancer biology, serving as a valuable tool for investigating cellular pathways and developing potential therapeutic strategies.

IUPAC: (-)-Nutlin-3,(-)-4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one,4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one,4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-Piperazinone,Nutlin 3a
Synonyms: (-)-Nutlin-3,(-)-4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one,4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one,4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-Piperazinone,Nutlin 3a

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Nutlin-3a (C30H30Cl2N4O4) — chemical structure, CAS 675576-98-4; Life Science, fine chemical supplied by Tech Serve Solutions

Apoptosis InducersApoptosis and Cell CycleCell Biology

01 /Applications

MDM2-p53 Interaction Inhibition

Nutlin-3a functions as a selective inhibitor of the MDM2-p53 interaction, thereby stabilizing and activating the p53 tumour suppressor protein. This mechanism is fundamental in cancer research for understanding and targeting cellular pathways involved in uncontrolled cell proliferation.

Apoptosis and Cell Cycle Studies

As an apoptosis inducer, Nutlin-3a is widely employed in research to investigate programmed cell death mechanisms. It also plays a significant role in studies concerning cell cycle progression and regulation, offering insights into cellular control points relevant to disease states.

Cellular Signaling Research

This compound is a valuable reagent in the field of cell signaling, particularly for exploring pathways modulated by the p53 pathway. Its use aids researchers in elucidating complex cellular responses and understanding disruptions that may lead to various pathologies.

02 /Properties

Molecular weight	581.49
Empirical formula	C30H30Cl2N4O4
Assay	≥98% (HPLC)
Form	powder
Colour	white to beige
Solubility	DMSO: soluble5 mg/mL, clear
Optical activity	[α]/D -140 to -155° (c=0.5, CDCl3)
Storage temperature	−20°C

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed

Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

675576-98-4

05 /Additional specifications

Shipped In	wet ice

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Nutlin-3a used for?

Nutlin-3a is used in biochemical research as an MDM2-p53 interaction inhibitor, a tool for studying apoptosis, cell cycle regulation, and cellular signaling pathways, particularly in the context of cancer research.

What is the CAS number and formula for Nutlin-3a?

The CAS number for Nutlin-3a is 675576-98-4, and its molecular formula is C30H30Cl2N4O4.

What grade and purity does Tech Serve Solutions supply for Nutlin-3a?

Tech Serve Solutions supplies Nutlin-3a with a purity of ≥98% (HPLC). This product is intended for research purposes and is not supplied as USP, BP, EP, or pharmaceutical grade.

How should Nutlin-3a be handled and stored?

Nutlin-3a is classified with the GHS07 symbol and a 'Warning' signal word due to the H302 hazard statement (Harmful if swallowed). It should be stored at −20°C. Handle with appropriate personal protective equipment in a well-ventilated area.