(+)-α-Methyl-4-carboxyphenylglycine

CAS 150145-89-4C10H11NO4Biochemicals & Reagents

(+)-α-Methyl-4-carboxyphenylglycine (CAS: 150145-89-4), with the molecular formula C10H11NO4 and a molecular weight of 209.20, is the active enantiomer of (±)-MCPG. This compound is a key reagent in biochemical research, particularly within the fields of cell biology, neuroscience, and GPCR modulation. It serves as a specific antagonist for certain metabotropic glutamate receptors, making it invaluable for studying excitatory amino acid neurotransmission and associated cellular signalling pathways.

IUPAC: (+)-MCPG,S(+)-α-Amino-4-carboxy-α-methyl-benzeneacetic acid
Synonyms: (+)-MCPGS-(+)-α-Amino-4-carboxy-α-methyl-benzeneacetic acid

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(+)-α-Methyl-4-carboxyphenylglycine (C10H11NO4) — chemical structure, CAS 150145-89-4; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCell BiologyExcitatory Amino AcidsGPCR ModulatorsGPCR ProteinsModulators and AntibodiesMetabotropic AntagonistsNeuroscienceNeurotransmission

01 /Applications

Neuroscience Research

Serves as a specific antagonist for metabotropic glutamate receptors (mGluRs), aiding in the investigation of neurotransmission and synaptic plasticity in neuronal systems.

Cell Signaling Studies

Utilised to explore cellular signalling pathways regulated by excitatory amino acids, particularly in the context of GPCR modulation and neuronal function.

Biochemical Assays

A valuable tool in biochemical assays for characterizing receptor activity and understanding the role of specific amino acid signalling in biological processes.

GPCR Modulator Research

Employed as a metabotropic antagonist to study the function and modulation of G protein-coupled receptors (GPCRs) involved in neurological functions.

02 /Properties

Molecular weight	209.20
Empirical formula	C10H11NO4
Form	solid
Solubility	0.1 M NaOH: soluble15 mg/mL
Optical activity	[α]20/D +89.54°, c = 0.33 in 6 M HCl(lit.)
Application	Active enantiomer of (±)-MCPG

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

150145-89-4

MDL number

MFCD00216858

PubChem substance

24896589

05 /Additional specifications

Gene Information	rat ... Grm1(24414)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is (+)-α-Methyl-4-carboxyphenylglycine used for?

(+)-α-Methyl-4-carboxyphenylglycine is primarily used as an active enantiomer of (±)-MCPG in neuroscience and cell biology research to study excitatory amino acid neurotransmission and GPCR modulation, acting as a specific antagonist for certain metabotropic glutamate receptors.

What are the CAS number and formula for (+)-α-Methyl-4-carboxyphenylglycine?

The CAS number for (+)-α-Methyl-4-carboxyphenylglycine is 150145-89-4, and its molecular formula is C10H11NO4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this chemical for research and laboratory use. The specific grade and purity are available upon request and are not represented as USP, BP, or EP grade.

What are the safety precautions for handling (+)-α-Methyl-4-carboxyphenylglycine?

Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound is classified with WGK Germany 3, indicating a high hazard to water.

How is this chemical shipped and exported?

Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and this product can be packed and shipped internationally according to regulatory requirements.