Lithium diisopropylamide mono(tetrahydrofuran) complex solution
Lithium diisopropylamide mono(tetrahydrofuran) complex solution (CAS 116912-61-9, Formula [(CH3)2CH]2NLi · C4H8O) is a potent, non-nucleophilic organolithium base. With a molecular weight of 179.23, it is commonly supplied as a solution for convenient handling in organic synthesis. Its primary applications include deprotonation reactions and as a strong base in the formation of carbanions for alkylation, condensation, and other carbon-carbon bond-forming processes in pharmaceutical and fine chemical manufacturing.
![Lithium diisopropylamide mono(tetrahydrofuran) complex solution ([(CH3)2CH]2NLi · C4H8O) — chemical structure, CAS 116912-61-9; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F116912-61-9.png&w=3840&q=75)
Deprotonation Agent
As a strong, non-nucleophilic base, Lithium diisopropylamide mono(tetrahydrofuran) complex solution is highly effective at deprotonating a wide range of carbon acids. It is particularly useful for generating enolates from ketones, esters, and amides.
Organometallic Reagent Synthesis
This reagent is crucial for the synthesis of various organometallic compounds by facilitating the formation of carbanions. These intermediates are vital in constructing complex molecular architectures in drug discovery and fine chemical synthesis.
Organic Synthesis
It serves as a versatile reagent in numerous organic transformations, including directed ortho-metallation, alkylations, and condensation reactions. Its tetrahydrofuran complexation enhances solubility and stability for ease of use in laboratory and industrial settings.
| Molecular weight | 179.23 |
|---|---|
| Linear formula | [(CH3)2CH]2NLi · C4H8O |
| Density | 0.816 g/mL at 20 °C |
| Concentration | ~1.5 M in cyclohexane |
| Storage temperature | 2-8°C |
| Impurities tested | ~10% ethylbenzene |
Hazard statements
- H225Highly flammable liquid and vapour
- H304May be fatal if swallowed and enters airways
- H314Causes severe skin burns and eye damage
- H332Harmful if inhaled
- H336May cause drowsiness or dizziness
- H410Very toxic to aquatic life with long-lasting effects
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -18 °C / -.4 °F |
| Transport (UN / ADR) | UN 2924 3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C,N |
| Risk statements (R) | 11-20-34-50/53-65 |
| Safety statements (S) | 16-26-36/37/39-45-61-62 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Shelf Life | (limited shelf life) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Lithium diisopropylamide mono(tetrahydrofuran) complex solution used for?
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Lithium diisopropylamide mono(tetrahydrofuran) complex solution is primarily used as a strong, non-nucleophilic base in organic synthesis for deprotonation reactions, particularly for generating enolates and carbanions in the formation of carbon-carbon bonds. It is a key reagent in the synthesis of pharmaceuticals and fine chemicals.
What is the CAS number and formula for this compound?
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The CAS number is 116912-61-9 and the linear formula is [(CH3)2CH]2NLi · C4H8O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Lithium diisopropylamide mono(tetrahydrofuran) complex solution as a technical/research grade reagent, typically at a concentration of ~1.5 M in cyclohexane with ~10% ethylbenzene as an impurity. TSS does not represent this product as USP, BP, or EP grade.
How should Lithium diisopropylamide mono(tetrahydrofuran) complex solution be handled safely?
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This compound is highly flammable and corrosive. Handle with extreme caution under an inert atmosphere, wearing appropriate personal protective equipment including a full-face respirator, chemical-resistant gloves, and eye protection. Avoid ignition sources and ensure adequate ventilation. Refer to the Safety Data Sheet for detailed handling procedures.
Is Lithium diisopropylamide mono(tetrahydrofuran) complex solution a controlled substance?
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No, the provided data does not indicate that Lithium diisopropylamide mono(tetrahydrofuran) complex solution is a controlled substance.
How is this chemical packed, shipped, and exported?
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Lithium diisopropylamide mono(tetrahydrofuran) complex solution is typically packed in containers suitable for flammable liquids and stored under refrigeration. TSS can manage export logistics to various global destinations, adhering to all relevant transportation regulations for hazardous materials like UN 2924.
How can I request a sample or quote for this chemical?
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To request a sample or obtain a quote, please visit the Tech Serve Solutions website and use the product inquiry form, or contact our sales team directly with your requirements, including the desired quantity and destination.
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