Lithium diethylamide
Lithium diethylamide (CAS: 816-43-3) is a potent organolithium base with the linear formula (C2H5)2NLi and a molecular weight of 79.07 g/mol. This highly reactive compound is primarily utilised as a strong, non-nucleophilic base in organic synthesis for deprotonation reactions, facilitating the formation of enolates and other carbanions in the preparation of complex organic molecules.
Strong Base in Organic Synthesis
Lithium diethylamide serves as a powerful base for various deprotonation reactions, including the formation of kinetic and thermodynamic enolates from carbonyl compounds. Its strong basicity is crucial for promoting aldol reactions and alkylations.
Deprotonation of Weakly Acidic Protons
This reagent effectively removes weakly acidic protons from substrates such as terminal alkynes, alcohols, and amines. This capability is instrumental in facilitating subsequent functionalisation or coupling reactions.
Precursor for Organometallic Reagents
It can be employed in the synthesis of other organometallic species or as a transmetallating agent in specific synthetic pathways. Its controlled reactivity allows for precise manipulation in multi-step syntheses.
| Molecular weight | 79.07 |
|---|---|
| Linear formula | (C2H5)2NLi |
| Assay | ≥95% |
Hazard statements
- H250Catches fire spontaneously if exposed to air
- H261In contact with water releases flammable gas
- H314Causes severe skin burns and eye damage
Precautionary statements
- P222Do not allow contact with air
- P231Handle under inert gas
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
- P422
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3393 4.2(4.3) |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 17-34 |
| Safety statements (S) | 16-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Lithium diethylamide (CAS 816-43-3) used for?
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Lithium diethylamide is primarily used as a strong, non-nucleophilic base in organic synthesis for deprotonation reactions, such as the formation of enolates. It is also used to remove weakly acidic protons from various organic substrates.
What is the CAS number and formula for Lithium diethylamide?
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The CAS number for Lithium diethylamide is 816-43-3, and its linear formula is (C2H5)2NLi.
What grade and purity does Tech Serve Solutions supply for Lithium diethylamide?
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Tech Serve Solutions supplies Lithium diethylamide with an assay of 0% or higher. This product is typically supplied for research and chemical synthesis purposes; TSS does not represent it as USP, BP, EP, or other pharmacopoeial grades.
How should Lithium diethylamide be handled and stored safely?
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Lithium diethylamide is highly reactive and pyrophoric, igniting spontaneously in air. It also reacts violently with water and causes severe skin burns and eye damage. Handle under an inert atmosphere (e.g., argon or nitrogen), wear appropriate personal protective equipment including eyeshields, face shields, and chemical-resistant gloves, and store away from moisture and air.
Is Lithium diethylamide a controlled substance?
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While the provided data does not explicitly classify Lithium diethylamide as a controlled substance, its hazardous properties require careful handling and compliance with relevant chemical safety regulations.
How is Lithium diethylamide packed, shipped, and exported?
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Lithium diethylamide is packed and shipped according to strict safety protocols for hazardous materials, often under an inert atmosphere, to ensure stability and prevent reaction with air or moisture. TSS exports this chemical globally, adhering to all international shipping regulations for dangerous goods.
How can I request a sample or quote for Lithium diethylamide?
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To request a sample or obtain a quote for Lithium diethylamide, please contact the Tech Serve Solutions sales team through our website or by phone. Provide your specific requirements and shipping details.
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