L-Pyroglutamic acid 2-naphthylamide
L-Pyroglutamic acid 2-naphthylamide (CAS: 22155-91-5) is a valuable chemical compound with the molecular formula C15H14N2O2 and a molecular weight of 254.28 g/mol. This modified amino acid serves as a specific substrate for pyroglutamate aminopeptidase. Its primary applications lie in biochemical research and diagnostics, particularly for the differentiation of bacterial species. Supplied by Tech Serve Solutions, it adheres to a high purity standard.
- IUPAC
- L-Pyroglutamic acid β-naphthylamide,L-Pyrrolidonyl-β-naphthylamide,N1-(2-Naphthyl)-L-pyroglutamic acid,PYR

Enzyme Substrate
L-Pyroglutamic acid 2-naphthylamide functions as a specific chromogenic substrate for the enzyme pyroglutamate aminopeptidase. This enzymatic activity can be detected and quantified in various biological and diagnostic assays.
Bacterial Differentiation
This compound is instrumental in clinical microbiology for differentiating between specific bacterial groups. It is notably used for distinguishing Group A streptococci and enterococci from other streptococcal species based on their enzymatic profiles.
Biochemical Research
As a modified amino acid derivative, it is employed in biochemical studies to investigate enzyme kinetics, protein modification, and related biological processes. Its defined structure makes it a reliable tool for laboratory investigations.
| Molecular weight | 254.28 |
|---|---|
| Empirical formula | C15H14N2O2 |
| Assay | ≥99% (TLC) |
| Storage temperature | 2-8°C |
| Application | A substrate for pyroglutamate aminopeptidase.1 Used for differentiation of Group A streptococci and enterococci from other streptococci.2 |

Hazard statements
- H400Very toxic to aquatic life
Precautionary statements
- P273Avoid release to the environment
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3077 9 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Risk statements (R) | 50/53 |
| Safety statements (S) | 60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is L-Pyroglutamic acid 2-naphthylamide used for?
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L-Pyroglutamic acid 2-naphthylamide (CAS: 22155-91-5) is primarily used as a substrate for pyroglutamate aminopeptidase and for the differentiation of Group A streptococci and enterococci from other streptococci.
What are the CAS number and molecular formula for L-Pyroglutamic acid 2-naphthylamide?
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The CAS number is 22155-91-5 and the molecular formula is C15H14N2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies L-Pyroglutamic acid 2-naphthylamide with an assay of ≥99% (TLC). We do not represent this product as USP, BP, or EP grade.
What are the key safety and handling considerations?
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L-Pyroglutamic acid 2-naphthylamide is classified under GHS09 with signal word Warning and hazard statement H400 (Very toxic to aquatic life). It requires the use of a dust mask (type N95), eyeshields, and gloves. Handle with appropriate personal protective equipment and ensure it is not released into the environment (P273).
How is L-Pyroglutamic acid 2-naphthylamide supplied and exported?
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This chemical is typically stored at 2-8°C. As per UN 3077, it is classified as 9 / PGIII for transport, indicating it is an environmentally hazardous substance, solid, n.o.s. Tech Serve Solutions is a global supplier and exporter.
How can I request a sample or quote for L-Pyroglutamic acid 2-naphthylamide?
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Please contact our sales team through our website or by phone to request a sample or a quotation for L-Pyroglutamic acid 2-naphthylamide.
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