Fmoc-D-Homophe-OH

CAS 135944-09-1C25H23NO4Chemical Synthesis

Fmoc-D-Homophe-OH (CAS: 135944-09-1) is an unnatural amino acid derivative with the formula C25H23NO4 and a molecular weight of 401.45 g/mol. This compound is a valuable building block in chemical synthesis, particularly within peptide chemistry and chemical biology. It serves as a key intermediate for the incorporation of non-standard amino acid residues into peptides, enabling the exploration of novel structures and functions.

IUPAC: (R)-2-(Fmoc-amino)-4-phenylbutyric acid,Fmoc-D-homophenylalanine

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Fmoc-D-Homophe-OH (C25H23NO4) — chemical structure, CAS 135944-09-1; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical BiologyChemical SynthesisHomo-Amino AcidsPeptide Chemistry

01 /Applications

Peptide Synthesis

Fmoc-D-Homophe-OH is utilized as a protected unnatural amino acid in solid-phase and solution-phase peptide synthesis. Its incorporation allows for the creation of modified peptides with altered conformational properties or biological activities.

Chemical Biology Research

This compound serves as a tool in chemical biology for constructing peptides with specific structural features not found in natural amino acids. This facilitates the study of protein-peptide interactions and the development of novel biomaterials.

Drug Discovery and Development

As a non-canonical amino acid derivative, Fmoc-D-Homophe-OH can be incorporated into peptide-based drug candidates. This modification can enhance metabolic stability, receptor binding affinity, or pharmacokinetic profiles.

Organic Synthesis

Beyond peptide chemistry, Fmoc-D-Homophe-OH can be employed in various organic synthesis pathways as a chiral building block for complex molecule construction.

02 /Properties

Molecular weight	401.45
Empirical formula	C25H23NO4
Assay	≥98.0% (HPLC)
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

135944-09-1

MDL number

MFCD00151917

Beilstein registry

4847668

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-D-Homophe-OH used for?

Fmoc-D-Homophe-OH is primarily used in peptide synthesis, chemical biology research, and drug discovery as a protected unnatural amino acid derivative for creating modified peptides and complex organic molecules.

What is the CAS number and chemical formula for Fmoc-D-Homophe-OH?

The CAS number is 135944-09-1, and the empirical formula (Hill notation) is C25H23NO4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-D-Homophe-OH with an assay of ≥98.0% determined by HPLC. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.

How should Fmoc-D-Homophe-OH be handled and stored?

Handle Fmoc-D-Homophe-OH with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store the compound at 2-8°C.