Diethyl fluoro(phenylsulfonyl)methylphosphonate
Diethyl fluoro(phenylsulfonyl)methylphosphonate (CAS: 114968-97-7) is a specialised organophosphorus compound with the molecular formula C11H16FO5PS and a molecular weight of 310.28 g/mol. This reagent is primarily utilised as a reactant in various synthetic organic chemistry transformations. Its applications include participation in radical-mediated thiodesulfonylation reactions and the preparation of specific chemical entities like phenyl fluorovinyl sulfones.
- IUPAC
- Diethyl [α-fluoro-α-(phenylsulfonyl)methyl]phosphonate,McCarthy′s reagent
Horner-Wadsworth-Emmons Reagents
This compound serves as a valuable reagent in Horner-Wadsworth-Emmons reactions, a widely used method for the synthesis of alkenes from carbonyl compounds and phosphonate esters.
C-C Bond Formation
It is employed in synthetic strategies that require the formation of carbon-carbon bonds, contributing to the construction of complex organic molecules.
Radical-Mediated Reactions
The compound participates in radical-mediated thiodesulfonylation reactions, enabling specific sulfur-containing functional group introductions.
Preparation of Phenyl Fluorovinyl Sulfones
It is a precursor in the synthesis of phenyl fluorovinyl sulfones, often achieved through Julia olefination methodologies.
Negishi Cross-Coupling
This phosphonate ester can be utilised in Negishi cross-coupling reactions, facilitating the formation of carbon-carbon bonds between organozinc reagents and organohalides.
| Molecular weight | 310.28 |
|---|---|
| Empirical formula | C11H16FO5PS |
| Assay | 97% |
| Application | Reactant for:• Radical-mediated thiodesulfonylation reactions1• Preparation of Bacillus subtilis S-ribosylhomocysteinase inhibitors2• Phenyl fluorovinyl sulfones via Julia olefination3• Horner-Wadsworth-Emmons reaction4• Negishi cross-coupling5 |
| Melting point | 61-65 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diethyl fluoro(phenylsulfonyl)methylphosphonate used for?
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Diethyl fluoro(phenylsulfonyl)methylphosphonate is used as a reactant in various synthetic organic chemistry applications, including Horner-Wadsworth-Emmons reactions, radical-mediated thiodesulfonylation, Julia olefination for preparing phenyl fluorovinyl sulfones, and Negishi cross-coupling reactions.
What are the CAS number and formula for Diethyl fluoro(phenylsulfonyl)methylphosphonate?
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The CAS number is 114968-97-7, and its molecular formula is C11H16FO5PS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Diethyl fluoro(phenylsulfonyl)methylphosphonate with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Diethyl fluoro(phenylsulfonyl)methylphosphonate be handled?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. Please consult the Safety Data Sheet for detailed handling and safety information.
How is Diethyl fluoro(phenylsulfonyl)methylphosphonate packed and shipped?
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This chemical is carefully packed and exported by Tech Serve Solutions in compliance with all relevant international shipping and hazardous materials regulations.
How can I request a sample or quote for Diethyl fluoro(phenylsulfonyl)methylphosphonate?
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To request a sample or a quotation, please contact our sales team through the website or by phone. We look forward to assisting with your chemical supply needs.
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