Dansyl fluoride
Dansyl fluoride (CAS 34523-28-9, C12H12FNO2S, MW 253.29) is a reactive fluorescent labelling agent. It is widely employed for the derivatisation of primary and secondary amines, thiols, and phenols, enabling sensitive detection via fluorescence spectroscopy. Its applications span biochemical research, chromatography, and the study of proteins and peptides, making it a valuable tool in analytical chemistry.
- IUPAC
- 5-(Dimethylamino)-1-naphthalenesulfonyl fluoride,DNSF
- Synonyms
- 5-(Dimethylamino)-1-naphthalenesulfonyl fluoride,DNSF
Fluorescent Labelling
Dansyl fluoride reacts with amine, thiol, and hydroxyl groups to form fluorescent derivatives. This allows for the sensitive detection and quantification of biomolecules like amino acids, peptides, and proteins using fluorescence spectroscopy.
Chromatographic Analysis
As a derivatisation reagent, dansyl fluoride is used to enhance the detectability of analytes in techniques such as High-Performance Liquid Chromatography (HPLC). The resulting dansylated compounds exhibit strong fluorescence, improving detection limits.
Biochemical Research
It serves as a probe in biochemical studies, aiding in the characterisation of protein structures and functions by labelling specific amino acid residues. Its fluorescence properties are crucial for tracking and analysing biological interactions.
| Molecular weight | 253.29 |
|---|---|
| Empirical formula | C12H12FNO2S |
| Assay | ≥99.0% (HPLC) |
| Grade | for fluorescence |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Fluorescence | λex 360 nm; λem 580 nm in methanol |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Dansyl fluoride used for?
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Dansyl fluoride is primarily used as a fluorescent labelling reagent for the derivatisation of primary and secondary amines, thiols, and phenols, enabling sensitive detection via fluorescence spectroscopy in biochemical research and chromatography.
What is the CAS number and formula for Dansyl fluoride?
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The CAS number for Dansyl fluoride is 34523-28-9, and its empirical formula is C12H12FNO2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Dansyl fluoride with an assay of ≥99.0% (HPLC), designated for fluorescence applications. We do not represent this product as USP, BP, or EP grade.
How should Dansyl fluoride be handled safely?
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Dansyl fluoride is a corrosive substance and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, must be worn. Handle in a well-ventilated area and seek immediate medical attention in case of exposure.
How is Dansyl fluoride packed, shipped, and exported?
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Dansyl fluoride is shipped as a hazardous material (UN 3261, Class 8, Packing Group II). TSS ensures compliance with all relevant shipping and export regulations for hazardous chemicals.
How can I request a sample or quote for Dansyl fluoride?
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To request a sample or quote for Dansyl fluoride, please contact our sales team through the website or by phone, providing your specific requirements and delivery details.
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