α-Cyano-2,4-difluorocinnamic acid
α-Cyano-2,4-difluorocinnamic acid (CAS: 953905-51-6) is a difluorinated cinnamic acid derivative with a molecular weight of 209.15 g/mol. It serves as a crucial matrix substance in mass spectrometry, particularly for Matrix-Assisted Laser Desorption/Ionization (MALDI) techniques. Its chemical structure makes it suitable for analysing various analytes including lipids, peptides, and fragile molecules, contributing to advancements in proteomics and molecular biology research.
- IUPAC
- α-Cyano-o,p-difluorocinnamic acid,2-Cyano-3-(2,4-difluorophenyl)-2-propenoic acid,DiFCCA
- Synonyms
- DiFCCA2-Cyano-3-(2,4-difluorophenyl)-2-propenoic acid
MALDI-MS Matrix Material
This compound is specifically formulated as a matrix substance for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS). It facilitates the ionization of analytes, enabling their detection and analysis.
Proteomics and Lipidomics
Its utility extends to the analysis of complex biological samples such as peptides and lipids in proteomics and lipidomics research. The matrix properties aid in the precise characterisation of these biomolecules.
Analysis of Fragile Analytes
α-Cyano-2,4-difluorocinnamic acid is suitable for analysing sensitive and fragile analytes, including drugs and chlorinated lipids, where gentle ionization is paramount.
Chromatography and Spectroscopy
The compound finds application in analytical and chromatography settings, contributing to spectroscopic analyses and method development within laboratories.
| Molecular weight | 209.15 |
|---|---|
| Empirical formula | C10H5F2NO2 |
| Assay | ≥95.0% (HPLC) |
| Grade | matrix substance for MALDI-MS |
| Solubility | methanol: soluble100 mg/10 mL, clear, colorless to light yellow |
| Application | suitable as MALDI-Matrix material |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36-37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Analyte Suitability | CID-MS/MSME-SIMSchlorinated lipidsdrugsfragile analytesionic liquids (quantification)lipidspeptidesphospholipidsphosphopeptides |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is α-Cyano-2,4-difluorocinnamic acid used for?
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α-Cyano-2,4-difluorocinnamic acid is primarily used as a matrix material for MALDI-MS, particularly for analysing peptides, lipids, fragile analytes, and in proteomics and molecular biology research.
What are the CAS number and formula for α-Cyano-2,4-difluorocinnamic acid?
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The CAS number is 953905-51-6 and the empirical formula (Hill notation) is C10H5F2NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies α-Cyano-2,4-difluorocinnamic acid with an assay of ≥95.0% (HPLC) and it is designated as a matrix substance for MALDI-MS. We do not represent this product as meeting USP, BP, or EP pharmacopoeia standards.
What are the safety considerations when handling this chemical?
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This compound is classified with a GHS07 symbol and a Warning signal word. It is harmful if swallowed, in contact with skin, or if inhaled (H302 + H312 + H332). It also causes skin irritation, serious eye irritation, and may cause respiratory irritation (H315-H319-H335). Always use appropriate personal protective equipment, including gloves, eye protection, and ensure adequate ventilation.
Is this product available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents and can export α-Cyano-2,4-difluorocinnamic acid.
How can I request a quote or sample?
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To request a quote or a sample of α-Cyano-2,4-difluorocinnamic acid, please contact our sales department through the website or by phone.
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