Boc-Thr(tBu)-OH

CAS 13734-40-2(CH3)3COCH(CH3)CH(COOH)NHCOOC(CH3)3Chemical Synthesis

Boc-Thr(tBu)-OH (CAS 13734-40-2) is a protected amino acid derivative, specifically a tert-butyl ester and Boc-protected L-threonine. With a molecular weight of 275.34 g/mol, this compound is a valuable building block in organic synthesis, particularly in peptide chemistry. Its protected nature allows for selective manipulation in complex multi-step synthetic routes, contributing to the development of novel peptides and related molecules. It is supplied for research and chemical synthesis applications.

IUPAC: Boc-O-tert-butyl-L-threonine

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Boc-Thr(tBu)-OH ((CH3)3COCH(CH3)CH(COOH)NHCOOC(CH3)3) — chemical structure, CAS 13734-40-2; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesChemical BiologyChemical SynthesisPeptide ChemistryThreonine

01 /Applications

Peptide Synthesis

Boc-Thr(tBu)-OH is extensively used in solid-phase and solution-phase peptide synthesis. The Boc and tert-butyl protecting groups facilitate controlled coupling reactions, enabling the sequential assembly of amino acid chains to form peptides with specific sequences and functionalities.

Organic Synthesis

As a protected amino acid, it serves as a versatile intermediate in broader organic synthesis. Its structure allows for further chemical modifications, making it useful in the creation of complex organic molecules beyond just peptides, including peptidomimetics and other biologically active compounds.

Chemical Biology Research

The compound finds application in chemical biology for creating modified peptides or probes used to study biological systems. These custom-synthesized molecules can help elucidate protein function, enzyme mechanisms, or cellular pathways.

02 /Properties

Molecular weight	275.34
Linear formula	(CH3)3COCH(CH3)CH(COOH)NHCOOC(CH3)3
Assay	≥99.0% (sum of enantiomers, TLC)
Optical activity	[α]20/D +3.6±0.5°, c = 2% in DMF
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

13734-40-2

MDL number

MFCD00151115

Beilstein registry

4454820

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Boc-Thr(tBu)-OH used for?

Boc-Thr(tBu)-OH is primarily used as a protected amino acid building block in peptide synthesis and general organic synthesis. It is also applied in chemical biology research for creating modified peptides and probes.

What are the CAS number and formula for Boc-Thr(tBu)-OH?

The CAS number for Boc-Thr(tBu)-OH is 13734-40-2. Its linear formula is (CH₃)₃COCH(CH₃)CH(COOH)NHCOOC(CH₃)₃.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Boc-Thr(tBu)-OH with an assay of ≥99.0% (sum of enantiomers, TLC). TSS does not represent this product as USP, BP, or EP grade; it is intended for research and chemical synthesis.

How should Boc-Thr(tBu)-OH be handled and stored?

For safe handling, use appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter may be necessary. The compound should be stored at 2-8°C.