5-Nitro-2-thiophenecarboxaldehyde
5-Nitro-2-thiophenecarboxaldehyde (CAS: 4521-33-9; Formula: C5H3NO3S) is a heterocyclic organic compound. It presents as a building block with a nitro group and an aldehyde functional group attached to a thiophene ring. This chemical serves as a versatile intermediate in organic synthesis, particularly for the development of novel pharmaceutical agents and functional materials. Its reactivity makes it valuable in diverse chemical transformations.

Organic Synthesis Intermediate
This compound acts as a crucial building block in the synthesis of more complex organic molecules. Its aldehyde and nitro functionalities allow for a variety of chemical reactions, facilitating the construction of diverse molecular architectures.
Pharmaceutical Research
It is employed in the development of potential drug candidates. The thiophene core and reactive groups are features found in various biologically active compounds, making it a useful starting material for medicinal chemistry exploration.
Materials Science
The unique structural features of 5-Nitro-2-thiophenecarboxaldehyde can be incorporated into novel materials. Its use may contribute to the synthesis of compounds with specific electronic or optical properties.
| Molecular weight | 157.15 |
|---|---|
| Empirical formula | C5H3NO3S |
| Assay | 98% |
| Solubility | acetone: soluble1%, clear, yellow |
| Melting point | 75-77 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Nitro-2-thiophenecarboxaldehyde used for?
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5-Nitro-2-thiophenecarboxaldehyde is primarily used as an intermediate in organic synthesis, particularly in pharmaceutical research and materials science, due to its nitro and aldehyde functional groups on a thiophene ring.
What is the CAS number and chemical formula for 5-Nitro-2-thiophenecarboxaldehyde?
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The CAS number is 4521-33-9 and the chemical formula is C5H3NO3S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound at an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 5-Nitro-2-thiophenecarboxaldehyde be handled safely?
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This compound is classified as an irritant (H315, H319, H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a dust mask (N95 type US recommended). Ensure adequate ventilation.
Is this chemical controlled or scheduled?
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Based on the provided data, there is no indication that this chemical is controlled or scheduled.
How is this chemical packed, shipped, or exported?
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Tech Serve Solutions carefully packs and handles chemicals for global export, adhering to all relevant shipping regulations to ensure safe and secure delivery.
How can I request a sample or quote for 5-Nitro-2-thiophenecarboxaldehyde?
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To request a sample or a detailed quotation, please contact our sales team through the website or by direct inquiry, providing your specific requirements.
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