3,3-Dimethylglutaric acid
3,3-Dimethylglutaric acid (CAS 4839-46-7) is an organic compound with the linear formula HOOCCH2C(CH3)2CH2COOH and a molecular weight of 160.17 g/mol. This carboxylic acid functions as a versatile building block in chemical synthesis. It is frequently employed as a reactant in the preparation of various complex organic molecules, including potential pharmaceutical agents and conjugates. Its structure lends itself to cyclisation reactions and the formation of diverse derivatives.
- IUPAC
- 3,3-Dimethylpentanedioic acid,NSC 14987,NSC 49114
- Synonyms
- HOOCCH2C(CH3)2CH2COOH3,3-Dimethylpentanedioic acid
Synthesis of Pharmaceutical Intermediates
3,3-Dimethylglutaric acid serves as a key reactant in the synthesis of compounds with potential therapeutic applications. Examples include the preparation of conjugates of betulin derivatives with anti-HIV activity and glycyrrhetinic acid derivatives investigated for proteasome inhibition.
Organic Synthesis Building Block
This dicarboxylic acid is utilized in various organic transformations. It participates in cyclodehydration reactions of diols and in catalytic, asymmetric transannular aldolizations, enabling the construction of complex molecular architectures.
Preparation of Biologically Active Molecules
The compound is involved in the preparation of dimeric peptide antagonists targeting IgG-FcRn interactions. It also finds application in the microwave-assisted protection of glutaraldehyde, a common reagent in organic chemistry.
| Molecular weight | 160.17 |
|---|---|
| Linear formula | HOOCCH2C(CH3)2CH2COOH |
| Assay | ≥98.0% (GC) |
| Grade | purum |
| Application | Reactant involved in:• Cyclodehydration of diols1• Synthesis of conjugates of betulin derivatives used as anti-HIV agents2• Preparation of dimeric peptide antagonists of IgG-FcRn interaction3• Microwave-assisted protection of glutaraldehyde4• Synthesis of glycyrrhetinic acid derivatives for proteasome inhibition5• Catalytic, asymmetric transannular aldolizations6 |
| Melting point | 100-102 °C(lit.)100-102 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,3-Dimethylglutaric acid used for?
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3,3-Dimethylglutaric acid is used as a reactant in organic synthesis, including the cyclodehydration of diols, synthesis of betulin derivative conjugates with anti-HIV activity, preparation of dimeric peptide antagonists, microwave-assisted protection of glutaraldehyde, synthesis of glycyrrhetinic acid derivatives, and catalytic asymmetric transannular aldolizations.
What are the CAS number and formula for 3,3-Dimethylglutaric acid?
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The CAS number for 3,3-Dimethylglutaric acid is 4839-46-7, and its linear formula is HOOCCH2C(CH3)2CH2COOH.
What grade and purity does Tech Serve Solutions supply for 3,3-Dimethylglutaric acid?
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Tech Serve Solutions supplies 3,3-Dimethylglutaric acid with a purity of ≥98.0% (GC) and a grade of 'purum'. This product is intended for laboratory and research use; we do not represent it as USP, BP, EP, or pharmacopoeia grade.
How should 3,3-Dimethylglutaric acid be handled safely?
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3,3-Dimethylglutaric acid is classified with H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). Handle with appropriate personal protective equipment, including a dust mask (N95 US type), eyeshields, and gloves, in a well-ventilated area. Avoid breathing dust.
Is 3,3-Dimethylglutaric acid a controlled substance?
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Based on the provided data, 3,3-Dimethylglutaric acid is not listed as a controlled substance. It is classified as an irritant (Xi).
How is 3,3-Dimethylglutaric acid packed and exported?
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3,3-Dimethylglutaric acid is available in various pack sizes suitable for laboratory and industrial requirements. As a global supplier, Tech Serve Solutions expertly handles the export of this chemical worldwide, adhering to all necessary shipping regulations.
How can I request a quote or sample for 3,3-Dimethylglutaric acid?
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To request a quote or a sample of 3,3-Dimethylglutaric acid, please use the 'Request a Quote' or 'Request Sample' button on our product page or contact our sales team directly via email or phone.
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