Zomepirac sodium salt
Zomepirac sodium salt (CAS 64092-48-4) is a notable NSAID with the molecular formula C15H13ClNO3Na and a molecular weight of 313.71 g/mol. It acts as a potent inhibitor of MRP-mediated multidrug resistance. This compound significantly enhances the cytotoxicity of various chemotherapy agents, including anthracyclines (doxorubicin, daunorubicin, epirubicin), teniposide, VP-16, and vincristine, making it a valuable research tool in cancer drug resistance studies.
- IUPAC
- 5-(p-Chlorobenzoyl)-1,4-dimethylpyrrole-2-acetic acid sodium-potassium salt
- Synonyms
- 5-(p-Chlorobenzoyl)-1,4-dimethylpyrrole-2-acetic acid sodium-potassium salt
Multidrug Resistance Circumvention
Zomepirac sodium salt is utilised to overcome multidrug resistance mediated by MRP transporters. Its ability to bypass these efflux pumps makes it instrumental in enhancing the efficacy of certain chemotherapeutic agents.
Enhancing Cytotoxicity of Chemotherapeutics
This compound significantly increases the cytotoxic effects of anthracyclines, teniposide, VP-16, and vincristine. This application is crucial for research aimed at improving the effectiveness of existing cancer treatments.
Cell Biology Research
As a bioactive small molecule, Zomepirac sodium salt serves as a valuable reagent in cell biology studies, particularly in understanding drug transport mechanisms and cellular responses to cytotoxic compounds.
Neuroscience and Cell Signaling
Its involvement in cell signaling pathways makes it a relevant compound for research in neuroscience, investigating cellular responses and potential therapeutic targets.
| Molecular weight | 313.71 |
|---|---|
| Linear formula | C15H13ClNO3Na |
| Application | An NSAID. Circumvents MRP-mediated multidrug resistance. Significantly increases the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine. |
Hazard statements
- H300Fatal if swallowed
- H311Toxic in contact with skin
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25 |
| Safety statements (S) | 22-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Zomepirac sodium salt used for?
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Zomepirac sodium salt is used as an NSAID that circumvents MRP-mediated multidrug resistance and significantly increases the cytotoxicity of certain chemotherapeutic agents like anthracyclines, teniposide, VP-16, and vincristine for research purposes.
What is the CAS number and molecular formula for Zomepirac sodium salt?
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The CAS number for Zomepirac sodium salt is 64092-48-4, and its molecular formula is C15H13ClNO3Na.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Zomepirac sodium salt primarily as a research-grade chemical. We do not claim USP, BP, or EP compliance unless explicitly stated on the product's Certificate of Analysis.
How is Zomepirac sodium salt handled and shipped?
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Zomepirac sodium salt is classified as acutely toxic and requires careful handling. It is shipped in compliance with relevant regulations for hazardous materials, including appropriate GHS labelling and packaging.
How can I request a sample or quote for Zomepirac sodium salt?
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To request a sample or a quote, please contact our sales department via the website or direct email, providing your contact details and the quantity required.
What are the main hazards associated with Zomepirac sodium salt?
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Zomepirac sodium salt is Dangerously Toxic (GHS06). It is harmful or fatal if swallowed, in contact with skin, or if inhaled (H300-H311-H331). Appropriate personal protective equipment, including eyeshields, faceshields, gloves, and P2 respirator cartridges, must be used.
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