Zaprinast
Zaprinast (CAS: 37762-06-4), a xanthine derivative with the molecular formula C13H13N5O2 and a molecular weight of 271.27 g/mol, is a selective inhibitor of cyclic nucleotide phosphodiesterases (PDEs). Primarily utilised in biochemical research, it serves as a valuable tool for investigating cellular signalling pathways, particularly those involving cyclic AMP (cAMP) and cyclic GMP (cGMP). Its role in modulating these second messengers makes it relevant for studies in cell biology and neuroscience.
- IUPAC
- 1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one
Phosphodiesterase Inhibition Studies
Zaprinast is widely employed as a research chemical to inhibit phosphodiesterase enzymes, specifically PDE2 and PDE4 isoforms. This allows researchers to probe the downstream effects of elevated intracellular cAMP and cGMP levels in various biological systems.
Cellular Signalling Research
By modulating cyclic nucleotide metabolism, Zaprinast aids in understanding complex cellular signalling cascades. It is used to investigate cellular responses, gene expression, and physiological processes influenced by PDE activity in fields such as cell biology and neuroscience.
Pharmacological Tool
As a well-characterised PDE inhibitor, Zaprinast serves as a pharmacological tool in pre-clinical research settings. It helps elucidate the roles of PDE enzymes in physiological and pathological conditions.
| Molecular weight | 271.27 |
|---|---|
| Empirical formula | C13H13N5O2 |
| Form | solid |
| Colour | white |
| Solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble0.11 mg/mLDMSO: soluble10 mg/mLH2O: insoluble |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... PDE2A(5138), PDE4A(5141), PDE4B(5142), PDE4D(5144) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Zaprinast used for?
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Zaprinast is used in scientific research as a selective inhibitor of cyclic nucleotide phosphodiesterases, primarily PDE2 and PDE4. It helps researchers study cellular signalling pathways, cyclic nucleotide metabolism, and related biological processes in cell biology and neuroscience research.
What are the CAS number and formula for Zaprinast?
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The CAS number for Zaprinast is 37762-06-4, and its molecular formula is C13H13N5O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Zaprinast typically as a research-grade chemical. The specific assay and purity are detailed on the Certificate of Analysis provided with the product. We do not represent this product as USP, BP, or EP grade.
How should Zaprinast be handled safely?
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Based on the provided safety data, Zaprinast is classified as a warning substance. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). When handling, use a dust mask type N95 (US), wear eyeshields, and use gloves. Ensure adequate ventilation.
Is Zaprinast a controlled substance?
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The provided data does not indicate that Zaprinast is a scheduled or controlled substance.
How is Zaprinast packed and shipped?
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Zaprinast is typically supplied as a white solid. Packaging and shipping methods comply with international regulations for chemical transport. TSS is a global supplier and exporter of fine chemicals.
How can I request a quote or sample for Zaprinast?
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To request a quote or sample for Zaprinast, please contact our sales team through the website or by phone, providing your contact details and the quantity required.
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