Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride

CAS 136132-67-7C30H39N9O6Biochemicals & Reagents

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride (CAS: 136132-67-7) is a fluorogenic substrate with the empirical formula C30H39N9O6 and a molecular weight of 621.69 g/mol. Supplied by Tech Serve Solutions, this compound is primarily utilised in biochemical research as a substrate for enzymes such as Cathepsin B. It is essential for assays investigating enzyme activity, particularly in studies related to apoptosis, cell signalling, and lysosomal function.

IUPAC: Z-RR-AMC

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Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride (C30H39N9O6) — chemical structure, CAS 136132-67-7; Life Science, fine chemical supplied by Tech Serve Solutions

Apoptosis and Cell CycleApplication IndexBioactive Small MoleculesBiochemicals and ReagentsCathepsin BCathepsins and GranzymesCell BiologyCell Signaling EnzymesEnzyme SubstratesEnzymes

01 /Applications

Enzyme Activity Assays

Serves as a sensitive fluorogenic substrate for quantifying the activity of specific proteases, particularly Cathepsin B and related enzymes. Its cleavage by target enzymes releases a fluorescent coumarin moiety, enabling real-time monitoring of enzyme kinetics.

Apoptosis and Cell Cycle Research

Utilised in research contexts exploring programmed cell death (apoptosis) and the regulation of the cell cycle, where the activity of specific proteases plays a critical role. This substrate aids in understanding the biochemical pathways involved in these cellular processes.

Biochemical and Cell Biology Studies

A valuable reagent for general biochemical research and cell biology investigations, particularly for studying intracellular signalling pathways and lysosomal enzyme function. It helps researchers probe enzyme mechanisms and cellular events.

02 /Properties

Molecular weight	621.69
Empirical formula	C30H39N9O6
Storage temperature	−20°C
Impurities tested	~4% isopropanol

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

136132-67-7

MDL number

MFCD00133576

05 /Additional specifications

Gene Information	human ... CTSB(1508)mouse ... CTSB(13030)rat ... CTSB(64529)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride used for?

This compound is a fluorogenic substrate primarily used in biochemical research for assaying the activity of enzymes like Cathespin B, and in studies related to apoptosis, cell cycle, and cell signalling.

What are the CAS number and empirical formula for Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride?

The CAS number is 136132-67-7, and the empirical formula is C30H39N9O6.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride with an impurity of ~4% isopropanol. TSS does not represent this product as USP, BP, or EP grade; it is intended for research purposes.

How should Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride be handled?

Handle with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. It is classified as a warning substance, causing skin irritation, serious eye irritation, and respiratory irritation (H315, H319, H335).

How is Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride shipped and exported?

As a specialist global supplier, Tech Serve Solutions exports Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride worldwide, adhering to all necessary shipping and regulatory requirements for chemical products.

How can I request a sample or quote for Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride?

To request a sample or a quote, please contact the Tech Serve Solutions sales department through the website or by phone, providing the product name and CAS number (136132-67-7).