VAS2870

CAS 722456-31-7C18H12N6OSCell Biology

VAS2870 (CAS 722456-31-7) is a chemical compound with the molecular formula C18H12N6OS and a molecular weight of 360.39 g/mol. It functions as a potent and selective inhibitor of soluble guanylate cyclase (sGC). This compound is primarily utilised in biochemical research for studying nitric oxide signalling pathways and their roles in various physiological and pathological processes. Its specific mechanism of action makes it a valuable tool in cell biology and neuroscience research.

IUPAC: 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide,7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine,7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine,VAS 2870,VAS-2870
Synonyms: 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidineVAS 2870VAS-2870

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VAS2870 (C18H12N6OS) — chemical structure, CAS 722456-31-7; Life Science, fine chemical supplied by Tech Serve Solutions

Cell BiologyNitric Oxide MetabolismNitric Oxide and Cell Stress

01 /Applications

Soluble Guanylate Cyclase (sGC) Inhibition

VAS2870 is a highly selective inhibitor of sGC, a key enzyme in the nitric oxide (NO) signalling pathway. It is used in research to investigate the physiological and pathophysiological roles of NO and sGC in various biological systems.

Nitric Oxide Signalling Research

This compound serves as a valuable tool for researchers studying the complex mechanisms of nitric oxide metabolism and its downstream effects, including vasodilation, neurotransmission, and cellular stress responses.

Cell Biology Studies

In cell biology, VAS2870 aids in dissecting signalling cascades involving cyclic guanosine monophosphate (cGMP) production. It helps elucidate cellular responses to NO and its regulators in diverse cell types.

Neuroscience Research

VAS2870 is employed in neuroscience to explore the involvement of the NO-sGC-cGMP pathway in neuronal function and dysfunction. It assists in understanding conditions affecting the nervous system.

02 /Properties

Molecular weight	360.39
Empirical formula	C18H12N6OS
Assay	≥97% (HPLC)
Solubility	DMSO: ≥5 mg/mL
Storage temperature	room temp

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed

Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

722456-31-7

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is VAS2870 used for?

VAS2870 is used as a potent and selective inhibitor of soluble guanylate cyclase (sGC) in biochemical and cell biology research. It is a valuable tool for studying nitric oxide signalling pathways, cellular stress, and related processes in cell biology and neuroscience.

What are the CAS number and molecular formula of VAS2870?

The CAS number for VAS2870 is 722456-31-7, and its molecular formula is C18H12N6OS.

What grade and purity does Tech Serve Solutions supply for VAS2870?

Tech Serve Solutions supplies VAS2870 with an assay of ≥97% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.

What are the safety considerations when handling VAS2870?

VAS2870 is classified with GHS07 symbol and a 'Warning' signal word. It carries the hazard statement H302, indicating it is harmful if swallowed. Appropriate personal protective equipment should be used, and contact with skin and eyes should be avoided. Handle in a well-ventilated area. Refer to the Safety Data Sheet for detailed handling instructions.

How is VAS2870 supplied and exported by Tech Serve Solutions?

VAS2870 is supplied at room temperature. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, ensuring reliable international shipment.