Trityl chloride
Trityl chloride (CAS 76-83-5), with the linear formula (C 6 H 5 ) 3 CCl and a molecular weight of 278.78 g/mol, is a key organic reagent. It is widely employed as a protecting group for amines, alcohols, and thiols in complex organic synthesis. Its ability to form stable trityl ethers and amines facilitates multi-step reactions, making it invaluable in the fine chemical and pharmaceutical industries.
- IUPAC
- Chlorotriphenylmethane,Triphenylchloromethane,Triphenylmethyl chloride
- Synonyms
- ChlorotriphenylmethaneTriphenylchloromethaneTriphenylmethyl chloride
Protecting Reagent for Amines
Trityl chloride is effectively used to introduce the trityl protecting group onto amine functionalities. This protection is crucial in peptide synthesis and other complex organic transformations where selective reactivity is required.
Protecting Reagent for Alcohols
The reagent serves to protect alcohol groups by forming trityl ethers. This application is vital in synthetic pathways involving sensitive alcohol functionalities, preventing unwanted side reactions.
Protecting Reagent for Thiols
Trityl chloride can also be employed to protect thiol groups. The resulting trityl thioethers are stable under various reaction conditions, aiding in the synthesis of sulfur-containing organic molecules.
Chemical Synthesis Intermediate
As a versatile synthetic reagent, trityl chloride finds application in various organic synthesis schemes. Its reactivity allows for the introduction of the triphenylmethyl moiety, useful in diverse chemical transformations.
| Molecular weight | 278.78 |
|---|---|
| Linear formula | (C6H5)3CCl |
| Assay | ≥97.0% (AT)≥97.0% (HPLC) |
| Boiling point | 230-235 °C/20 mmHg(lit.) |
| Solubility | chloroform: soluble0.1 g/mL, clear |
| Application | Protecting reagent for amines, alcohols, and thiols.1,2 |
| Melting point | 109-112 °C(lit.)109-113 °C |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
| Ignition residue | ≤0.2% (as SO4) |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trityl chloride primarily used for?
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Trityl chloride is primarily used as a protecting reagent for amines, alcohols, and thiols in organic synthesis.
What are the CAS number and formula for Trityl chloride?
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The CAS number for Trityl chloride is 76-83-5, and its linear formula is (C 6 H 5 ) 3 CCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Trityl chloride with an assay of ≥97.0% (AT) or ≥97.0% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Trityl chloride be handled safely?
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Trityl chloride is corrosive and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection (N100 or P3 filters), must be used. Handle in a well-ventilated area and avoid contact with skin, eyes, and clothing.
How is Trityl chloride packaged and shipped?
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Trityl chloride is packaged according to UN 3261, Class 8, Packing Group III. TSS exports globally, adhering to all relevant shipping regulations.
How can I request a quote or sample of Trityl chloride?
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To request a quote or sample of Trityl chloride, please contact our sales department via the website or phone.
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