Tris(3-hydroxypropyltriazolylmethyl)amine
Tris(3-hydroxypropyltriazolylmethyl)amine (CAS: 760952-88-3) is a key organic building block with the molecular formula C18H30N10O3 and a molecular weight of 434.50 g/mol. This compound serves as an effective ligand in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, a fundamental tool in click chemistry. It is widely utilized in chemical biology and synthesis for its role in efficient bioconjugation and material science applications.
- IUPAC
- 3,3′,3′′-(4,4′,4′′-(Nitrilotris(methylene))tris(1H-1,2,3-triazole-4,1-diyl))tris(propan-1-ol),THPTA
- Synonyms
- 3,3′,3′′-(4,4′,4′′-(Nitrilotris(methylene))tris(1H-1,2,3-triazole-4,1-diyl))tris(propan-1-ol),THPTA

Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC)
This compound functions as an effective ligand in CuAAC reactions, also known as click chemistry. It facilitates the efficient formation of triazole rings, crucial for various synthetic and biological applications.
Chemical Biology
Its ability to participate in click chemistry makes it valuable for bioconjugation, allowing for the labeling and modification of biomolecules. This aids in studying biological processes and developing new diagnostics.
Organic Synthesis
As a versatile organic building block, it is employed in the synthesis of complex molecules and novel materials. Its triazole structure offers unique properties for advanced chemical research.
| Molecular weight | 434.50 |
|---|---|
| Empirical formula | C18H30N10O3 |
| Assay | 95% |
| Storage temperature | 2-8°C |
| Application | Effective ligand for copper-catalyzed azide-alkyne cycloadditions (CuAAC). |
| Melting point | 331-336 °C (decomposition) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tris(3-hydroxypropyltriazolylmethyl)amine primarily used for?
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Tris(3-hydroxypropyltriazolylmethyl)amine is primarily used as an effective ligand for copper-catalyzed azide-alkyne cycloadditions (CuAAC), a key reaction in click chemistry, and in applications within chemical biology and organic synthesis.
What are the CAS number and molecular formula for Tris(3-hydroxypropyltriazolylmethyl)amine?
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The CAS number for Tris(3-hydroxypropyltriazolylmethyl)amine is 760952-88-3, and its molecular formula is C18H30N10O3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tris(3-hydroxypropyltriazolylmethyl)amine with an assay of 95%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Tris(3-hydroxypropyltriazolylmethyl)amine be handled and stored?
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Handle Tris(3-hydroxypropyltriazolylmethyl)amine with appropriate personal protective equipment to avoid skin and eye irritation, and respiratory tract irritation. Store in a cool place at 2-8°C.
Is Tris(3-hydroxypropyltriazolylmethyl)amine a controlled substance?
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The provided data does not indicate that Tris(3-hydroxypropyltriazolylmethyl)amine is a controlled substance.
How can I request a sample or quote for Tris(3-hydroxypropyltriazolylmethyl)amine?
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To request a sample or quote for Tris(3-hydroxypropyltriazolylmethyl)amine, please contact our sales team through the website or by phone.
How is Tris(3-hydroxypropyltriazolylmethyl)amine packed, shipped, and exported?
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Tris(3-hydroxypropyltriazolylmethyl)amine is packed according to industry standards for chemical reagents and is available for global export. Specific packing and shipping details can be provided upon request.
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