α-(Trimethylsilyloxy)phenylacetonitrile
α-(Trimethylsilyloxy)phenylacetonitrile (CAS 25438-37-3) is an organic compound with the linear formula (CH3)3SiOCH(CN)C6H5 and a molecular weight of 205.33 g/mol. This silyloxy derivative of phenylacetonitrile serves as a valuable building block in organic synthesis. Its chemical structure lends itself to various reactions, making it a useful intermediate in the development of more complex molecules for research and potential industrial applications.
- IUPAC
- Phenyl-trimethylsilanyloxy-acetonitrile
- Synonyms
- Phenyl-trimethylsilanyloxy-acetonitrile

Organic Synthesis Intermediate
Utilised as a key building block in complex organic synthesis pathways. Its unique functional groups allow for diverse chemical transformations, enabling the creation of novel molecular architectures.
Chemical Research Reagent
Serves as a specialised reagent for laboratory research and development. It is employed in academic and industrial settings for exploring new synthetic methodologies and developing novel compounds.
Nitrogen Compound Precursor
As a cyanide and nitrogen-containing compound, it can be a precursor for synthesising various nitrogen-based organic molecules. This makes it relevant in fields requiring nitrogen-rich compounds.
| Molecular weight | 205.33 |
|---|---|
| Linear formula | (CH3)3SiOCH(CN)C6H5 |
| Assay | 97% |
| Boiling point | 91 °C/0.5 mmHg(lit.) |
| Density | 0.978 g/mL at 25 °C(lit.) |

Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22 |
| Safety statements (S) | 7/9-23-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is α-(Trimethylsilyloxy)phenylacetonitrile used for?
+
α-(Trimethylsilyloxy)phenylacetonitrile is primarily used as a building block and intermediate in organic synthesis and chemical research.
What are the CAS number and chemical formula for α-(Trimethylsilyloxy)phenylacetonitrile?
+
The CAS number is 25438-37-3, and the linear formula is (CH3)3SiOCH(CN)C6H5.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this compound with an assay of 97%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should α-(Trimethylsilyloxy)phenylacetonitrile be handled safely?
+
This compound is classified as harmful if swallowed, in contact with skin, or if inhaled (H302-H312-H332). Appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection (e.g., type ABEK respirator filter), must be used. Handle in a well-ventilated area. Consult the safety data sheet for comprehensive guidance.
Is this chemical exported by Tech Serve Solutions?
+
Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals.
How can I request a sample or quote?
+
To request a sample or a quotation, please contact our sales department through the website or by phone, providing the product name and CAS number.
▶ Related products

1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis

1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis