trans-2-Chloromethylvinylboronic acid pinacol ester
trans-2-Chloromethylvinylboronic acid pinacol ester (CAS: 153724-93-7), with the molecular formula C9H16BClO2, is a valuable organoboron compound. This ester features a chlorinated vinyl group attached to a pinacol boronate moiety. Its structure makes it a versatile building block in organic synthesis, particularly for carbon-carbon bond formation via cross-coupling reactions. Tech Serve Solutions supplies this reagent for various research and development applications.
- IUPAC
- (E)-2-(3-Chloro-1-propenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane,E-2-Chloromethylvinylboronic acid pinacol ester
- Synonyms
- (E)-2-(3-Chloro-1-propenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Organic Synthesis Intermediate
This compound serves as a key intermediate in the synthesis of complex organic molecules. Its reactive boronate ester functionality allows for participation in Suzuki-Miyaura coupling reactions, enabling the introduction of the chloromethylvinyl group into various molecular architectures.
Cross-Coupling Reactions
Utilised in palladium-catalysed cross-coupling reactions, trans-2-Chloromethylvinylboronic acid pinacol ester facilitates the formation of new carbon-carbon bonds. It is particularly useful for constructing substituted alkenes and other unsaturated systems in pharmaceutical and material science research.
Pharmaceutical Research
As a building block, this boronate ester can be employed in the development of novel pharmaceutical candidates. Its specific structural features may contribute to the biological activity or pharmacokinetic properties of potential drug molecules.
| Molecular weight | 202.49 |
|---|---|
| Empirical formula | C9H16BClO2 |
| Assay | 97% |
| Boiling point | 57-62 °C/0.3-0.4 mmHg |
| Density | 1.028 g/mL at 25 °C |
| Refractive index | n20/D 1.4603 |
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | 100 °C / 212 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is trans-2-Chloromethylvinylboronic acid pinacol ester used for?
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trans-2-Chloromethylvinylboronic acid pinacol ester is primarily used as an intermediate and building block in organic synthesis, particularly for cross-coupling reactions like the Suzuki-Miyaura coupling, and in pharmaceutical research.
What is the CAS number and formula for trans-2-Chloromethylvinylboronic acid pinacol ester?
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The CAS number is 153724-93-7, and its empirical formula is C9H16BClO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies trans-2-Chloromethylvinylboronic acid pinacol ester with a minimum assay of 97%. This product is supplied for research and development purposes and is not represented as USP, BP, EP, or pharmacopoeia grade.
How is trans-2-Chloromethylvinylboronic acid pinacol ester handled and shipped?
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This compound has a flash point of 100 °C (212 °F) and requires appropriate safety precautions. It is classified under WGK Germany 3. Handling requires Eyeshields, Gloves, and suitable respiratory protection. Consult the Safety Data Sheet for detailed handling instructions. We export globally following all relevant regulations.
How can I request a quote or sample?
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To request a quote or sample of trans-2-Chloromethylvinylboronic acid pinacol ester, please visit the Tech Serve Solutions website and use our online contact form or contact our sales department directly.
Are there any specific storage requirements?
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While specific storage instructions are detailed in the Safety Data Sheet, organoboron compounds are typically stored in cool, dry conditions away from incompatible materials to maintain stability and reactivity.
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