trans-2-(4-Fluorophenyl)vinylboronic acid
trans-2-(4-Fluorophenyl)vinylboronic acid (CAS: 214907-24-1), with the molecular formula C8H8BFO2 and a molecular weight of 165.96 g/mol, is a valuable organoboronic acid derivative. It serves as a key reactant in organic synthesis, particularly in Suzuki-Miyaura coupling reactions and the preparation of complex organic molecules with potential biological and pharmacological activities. This compound is essential for advanced chemical research and development.
Suzuki-Miyaura Coupling Reactions
This boronic acid is an effective coupling partner in palladium-catalysed Suzuki-Miyaura reactions, facilitating the formation of carbon-carbon bonds with aryl or vinyl halides. This is a cornerstone reaction for synthesising complex organic structures.
Synthesis of Biologically Active Molecules
It is employed in the preparation of molecules that exhibit biological and pharmacological relevance. Its structure allows for the introduction of a fluorophenyl vinyl moiety into drug candidates and other bioactive compounds.
Conjugate Addition Reactions
The compound can participate in conjugate addition reactions, enabling the formation of new carbon-carbon bonds at the beta-position of alpha,beta-unsaturated carbonyl compounds. This expands its utility in synthetic organic chemistry.
| Molecular weight | 165.96 |
|---|---|
| Linear formula | FC6H4CH=CHB(OH)2 |
| Assay | 95% |
| Application | Reactant for:• Suzuki-Miyaura coupling reactions1• Preparation of biologically and pharmacologically active molecules2,3• Conjugate addition reactions4 |
| Melting point | 182-186 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is trans-2-(4-Fluorophenyl)vinylboronic acid used for?
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trans-2-(4-Fluorophenyl)vinylboronic acid is primarily used as a reactant in Suzuki-Miyaura coupling reactions, for the preparation of biologically and pharmacologically active molecules, and in conjugate addition reactions.
What is the CAS number and molecular formula for trans-2-(4-Fluorophenyl)vinylboronic acid?
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The CAS number is 214907-24-1, and the molecular formula is FC6H4CH=CHB(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies trans-2-(4-Fluorophenyl)vinylboronic acid with an assay of 95%. This product is suitable for research and chemical synthesis purposes and is not supplied as USP, BP, or EP grade.
What are the key safety considerations for handling this chemical?
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When handling trans-2-(4-Fluorophenyl)vinylboronic acid, it is crucial to use safety measures such as eyeshields and gloves. A respirator filter of type N95 (US) or P1 (EN143) should be used if necessary, and handling should occur in a well-ventilated area.
How is this chemical shipped and exported?
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Tech Serve Solutions specialises in the global supply and export of fine chemicals. This product is carefully packaged and shipped in compliance with international regulations for chemical transport.
How can I request a sample or quote for trans-2-(4-Fluorophenyl)vinylboronic acid?
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To request a sample or a quotation, please contact our sales department through the website or by phone, providing your contact details and the quantity required.
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