trans-1,4-Dichloro-2-butene
trans-1,4-Dichloro-2-butene (CAS: 110-57-6) is a halogenated hydrocarbon with the molecular formula ClCH₂CH=CHCH₂Cl and a molecular weight of 125.00 g/mol. This compound serves as a key building block in organic synthesis. It is primarily utilised in the chemical industry for the preparation of various complex organic molecules and intermediates.
- Synonyms
- ClCH2CH=CHCH2Cl
Synthesis of Tetrahydrofuran Derivatives
trans-1,4-Dichloro-2-butene is employed as a starting reagent for the synthesis of trans-tetrahydrofuran (THF) ring building blocks, crucial components in various organic syntheses.
Preparation of Swainsonine
This dichloroalkene is utilised in the chemical synthesis of swainsonine, a complex indolizidine alkaloid with significant biological interest.
Synthesis of 9-Alkylpurines
The compound finds application in the synthesis of 9-alkylpurines, which are important structural motifs in medicinal chemistry and biochemistry.
| Molecular weight | 125.00 |
|---|---|
| Linear formula | ClCH2CH=CHCH2Cl |
| Assay | 85% |
| Boiling point | 74-76 °C/40 mmHg(lit.) |
| Density | 1.183 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.488(lit.) |
| Vapour pressure | 10 mmHg (20 °C) |
| Melting point | 1-3 °C(lit.) |
| Storage temperature | 2-8°C |
| Application | trans-1,4-Dichloro-2-butene was used as starting reagent in the synthesis of trans-tetrahydrofuran (THF) ring building block1. It was also employed in the chemical synthesis of swainsonine [(1S,2R,8R,8 αR)-trihydroxyindolizidine]2 and 9-alkylpurines3. |
Hazard statements
- H226Flammable liquid and vapour
- H301Toxic if swallowed
- H312Harmful in contact with skin
- H314Causes severe skin burns and eye damage
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 53 °C / 127.4 °F |
| Transport (UN / ADR) | UN 3390 6.1/PG 1 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 10-21-25-26-34 |
| Safety statements (S) | 53-23-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is trans-1,4-Dichloro-2-butene used for?
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trans-1,4-Dichloro-2-butene is used as a starting reagent in the synthesis of trans-tetrahydrofuran (THF) ring building blocks, and in the chemical synthesis of swainsonine and 9-alkylpurines.
What are the CAS number and formula for trans-1,4-Dichloro-2-butene?
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The CAS number is 110-57-6, and the linear formula is ClCH₂CH=CHCH₂Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies trans-1,4-Dichloro-2-butene with a minimum assay of 85%. This product is supplied for research and development purposes and is not intended for USP, BP, EP, or other pharmacopoeial applications unless explicitly stated.
How should trans-1,4-Dichloro-2-butene be handled safely?
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trans-1,4-Dichloro-2-butene is a highly hazardous substance. It is flammable, toxic if swallowed, toxic in contact with skin, and causes severe skin burns and eye damage. Handle with extreme caution in a well-ventilated area, wearing appropriate personal protective equipment including a full-face respirator, chemical-resistant gloves, and eye protection. Refer to the Safety Data Sheet (SDS) for comprehensive handling instructions.
How is trans-1,4-Dichloro-2-butene packed and exported?
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Tech Serve Solutions packs and exports trans-1,4-Dichloro-2-butene in compliance with international regulations for hazardous materials, ensuring safe transit and handling.
How can I request a quote or sample?
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To request a quote or a sample of trans-1,4-Dichloro-2-butene, please contact our sales department via the website or by telephone. Our team will be pleased to assist you.
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