Thioacetic acid
Thioacetic acid (CAS 507-09-5), with the linear formula CH₃COSH and a molecular weight of 76.12 g/mol, is a key reagent used for the introduction of thiol groups into organic molecules. This volatile liquid, assaying at 96%, is a valuable tool in synthetic organic chemistry, enabling the formation of thioester linkages and other sulfur-containing compounds. Its characteristic pungent odour necessitates careful handling under appropriate laboratory conditions.
- IUPAC
- Thiacetic acid
- Synonyms
- Thiacetic acid
Thiolation Reagent
Thioacetic acid is primarily employed as a reagent for the efficient introduction of the thiol (-SH) functional group into various organic substrates. This process is fundamental in the synthesis of sulfur-containing organic compounds.
Synthesis of Thioesters
It serves as a direct precursor for the formation of thioesters through reactions with acyl halides or anhydrides. Thioesters are important intermediates in organic synthesis and can be found in biologically relevant molecules.
Protecting Group Chemistry
The thioacetyl group can function as a protecting group for alcohols or amines in multi-step syntheses, offering selective deprotection strategies.
Precursor for Sulfur Heterocycles
Thioacetic acid can be utilized in the construction of sulfur-containing heterocyclic rings, which are prevalent in pharmaceuticals and materials science.
| Molecular weight | 76.12 |
|---|---|
| Linear formula | CH3COSH |
| Assay | 96% |
| Boiling point | 88-91.5 °C(lit.) |
| Density | 1.065 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.465(lit.) |
| Storage temperature | 2-8°C |
| Application | Reagent for introduction of the thiol group into organic molecules. |
Hazard statements
- H225Highly flammable liquid and vapour
- H301Toxic if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 11 °C / 51.8 °F |
| Transport (UN / ADR) | UN 2436 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-34 |
| Safety statements (S) | 9-16-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Thioacetic acid used for?
+
Thioacetic acid is a reagent for introducing the thiol group into organic molecules and is used in the synthesis of thioesters and sulfur-containing heterocycles.
What is the CAS number and chemical formula for Thioacetic acid?
+
The CAS number is 507-09-5 and the linear chemical formula is CH₃COSH.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Thioacetic acid with an assay of 96%. We do not represent this product as USP, BP, EP, or any pharmacopoeia grade.
How should Thioacetic acid be handled safely?
+
Thioacetic acid is flammable and corrosive, causing severe skin burns and eye damage. Handle with extreme care, using appropriate personal protective equipment including gloves, eye protection, and respiratory protection in a well-ventilated area.
Is Thioacetic acid a controlled substance?
+
The provided data does not indicate that Thioacetic acid is a controlled substance.
How is Thioacetic acid packed, shipped, and exported?
+
Thioacetic acid is packed, shipped, and exported in compliance with all relevant national and international regulations for hazardous materials. Specific packaging and shipping details are available upon request.
How can I request a quote or sample of Thioacetic acid?
+
To request a quote or a sample of Thioacetic acid, please contact our sales team through the website or by phone, providing your requirements.
▶ Related products
5-Sulfosalicylic acid dihydrate
HO3SC6H3-2-(OH)CO2H 2H2O
Acids & Bases
Calcium hydroxide
Ca(OH)2
Acids & Bases
Acetic acid-12C2
12CH312CO2H
Acids & Bases
Acetic acid-13C2
13CH313CO2H
Acids & Bases
Acetic acid-13C2,d4
Acids & Bases
Acetic acid-17O2
CH3C17O2H
Acids & Bases
Acetic acid-18O2
CH3C18O2H
Acids & Bases
Acetic acid-2,2,2-d3
2-d3
Acids & Bases▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis