Tetraethylammonium fluoride dihydrate
Tetraethylammonium fluoride dihydrate (CAS 63123-01-3) is a chemical compound with the linear formula (C2H5)4N(F) · 2H2O and a molecular weight of 185.28 g/mol. This reagent serves as a valuable tool in organic synthesis, particularly as a fluoride source and a catalyst. Its applications include facilitating oxidation, methylation, and deuteration reactions, making it a useful component in the development of new chemical entities and research processes.

Catalysis in Organic Synthesis
Tetraethylammonium fluoride dihydrate acts as a catalyst in various organic transformations. It is particularly noted for its role in promoting oxidation, methylation, and deuteration reactions, contributing to the synthesis of complex molecules.
Fluoride Source
As a source of fluoride ions, this compound can be employed in reactions requiring nucleophilic fluorination. Its solubility and reactivity profile make it a convenient reagent for introducing fluorine atoms into organic structures.
Deprotection Reagent
In specific synthetic pathways, tetraethylammonium fluoride dihydrate can be utilized for the cleavage of certain protecting groups. This application aids in the stepwise construction of target molecules.
| Molecular weight | 185.28 |
|---|---|
| Linear formula | (C2H5)4N(F) · 2H2O |
| Assay | ≥97.0% (NT) |
| Storage temperature | 2-8°C |
| Application | • Catalyst for oxidation, methylation, and deuteration reactions of fluorene1 |

Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tetraethylammonium fluoride dihydrate used for?
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Tetraethylammonium fluoride dihydrate is primarily used as a catalyst for oxidation, methylation, and deuteration reactions of fluorene. It also functions as a fluoride source and a deprotecting reagent in organic synthesis.
What is the CAS number and formula for Tetraethylammonium fluoride dihydrate?
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The CAS number for Tetraethylammonium fluoride dihydrate is 63123-01-3, and its linear formula is (C2H5)4N(F) · 2H2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tetraethylammonium fluoride dihydrate with an assay of ≥97.0% (NT). We do not represent this product as meeting USP, BP, or EP pharmacopoeia standards.
How should Tetraethylammonium fluoride dihydrate be handled safely?
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Tetraethylammonium fluoride dihydrate is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and serious eye irritation. Appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, should be used. Ensure adequate ventilation and avoid breathing dust. In case of contact, rinse immediately and thoroughly.
How is Tetraethylammonium fluoride dihydrate packed and exported?
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Tetraethylammonium fluoride dihydrate is carefully packed according to international shipping regulations to ensure safe transport. TSS is a specialist global supplier and exporter of fine chemicals.
How can I request a sample or quote for Tetraethylammonium fluoride dihydrate?
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To request a sample or a quote for Tetraethylammonium fluoride dihydrate, please contact our sales team through the website or by phone. We will be pleased to assist you with your specific requirements.
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